Evidence map›Paper›PMID 40157902›Full record

ArticleNature communications2025

β-Carotene alleviates substrate inhibition caused by asymmetric cooperativity.

Jieren Liao, Umar F Shahul Hameed, Timothy D Hoffmann, Elisabeth Kurze, Guangxin Sun, Wieland Steinchen, Alessandro Nicoli, Antonella Di Pizio, Christina Kuttler, Chuankui Song and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Enzyme Catalytic Parameters and Evolution Across the Dissipation Plane.International journal of molecular sciences · 2026
    Review
  4. Article
  5. HalophyticACS omega · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jieren Liao *Biotechnology of Natural Products, School of Life Sciences, Technical University of Munich, 85354, Freising, Germany.
Umar F Shahul Hameed *KAUST Center of Excellence for Smart Health, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Timothy D HoffmannBiotechnology of Natural Products, School of Life Sciences, Technical University of Munich, 85354, Freising, Germany.ORCID http://orcid.org/0000-0001-8505-7126
Elisabeth KurzeBiotechnology of Natural Products, School of Life Sciences, Technical University of Munich, 85354, Freising, Germany.
Guangxin SunBiotechnology of Natural Products, School of Life Sciences, Technical University of Munich, 85354, Freising, Germany.
Wieland SteinchenCenter for Synthetic Microbiology (SYNMIKRO), Philipps-University Marburg, 35043, Marburg, Germany.
Alessandro NicoliLeibniz Institute for Food Systems Biology at the Technical University of Munich, 85354, Freising, Germany.ORCID http://orcid.org/0000-0001-6177-9749
Antonella Di PizioLeibniz Institute for Food Systems Biology at the Technical University of Munich, 85354, Freising, Germany.ORCID http://orcid.org/0000-0002-8520-5165
Christina KuttlerAnalysis and Mathematical Biology, Technical University of Munich, School of Computation, Information and Technology, 85748, Garching, Germany.ORCID http://orcid.org/0000-0002-5521-4159
Chuankui SongState Key Laboratory of Tea Plant Biology and Utilization, International Joint Laboratory on Tea Chemistry and Health Effects, Anhui Agricultural University, 230036, Hefei, Anhui, China.
Dragana A M CaticiCenter for Protein Assemblies (CPA), Technical University of Munich, 85748, Garching, Germany.
Farhah Assaad-GerbertBiotechnology of Natural Products, School of Life Sciences, Technical University of Munich, 85354, Freising, Germany.ORCID http://orcid.org/0000-0002-8683-9039
Thomas HoffmannBiotechnology of Natural Products, School of Life Sciences, Technical University of Munich, 85354, Freising, Germany.ORCID http://orcid.org/0009-0002-9366-9733
Stefan T AroldKAUST Center of Excellence for Smart Health, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.ORCID http://orcid.org/0000-0001-5278-0668
Wilfried G SchwabBiotechnology of Natural Products, School of Life Sciences, Technical University of Munich, 85354, Freising, Germany. wilfried.schwab@tum.de.ORCID http://orcid.org/0000-0002-9753-3967

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) SCHW 634/34-1
6 · The paper itself

Abstract

Enzymes are essential catalysts in biological systems. Substrate inhibition, once dismissed, is now observed in 20% of enzymes

Indexed as

beta CaroteneGlucosyltransferasesNicotianaPlant ProteinsCrystallography, X-RayGlucoseKineticsModels, MolecularSubstrate Specificitybeta CaroteneGlucoseGlucosyltransferasesPlant Proteins

Identifiers

PMID40157902
PMCPMC11954892

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.