Evidence map›Paper›PMID 40158161›Full record

ArticleHereditas2025

Infiltrating B-cell subtypes and associated hub genes in nasopharyngeal carcinoma identified from integrated single-cell, bulk RNA-sequencing, and immunohistochemical data.

Fangyan Zhong, Junjun Chen, Tianzhu Lu, Lin Zhang, Zhiliang Liu, Chunhong Guan, Xiaopeng Xiong, Xiaochang Gong, Jingao Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hereditas, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. B cells in cancer: functions, mechanisms and therapeutic advances.Signal transduction and targeted therapy · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fangyan Zhong *Jiangxi Medical College, Nanchang University, Nanchang, China.
Junjun Chen *Department of Pharmacology, School of Pharmacy, Nanchang University, Nanchang, China.
Tianzhu Lu *NHC Key Laboratory of Personalized Diagnosis and Treatment for Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, Nanchang, China.
Lin ZhangNHC Key Laboratory of Personalized Diagnosis and Treatment for Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, Nanchang, China.
Zhiliang LiuDepartment of pathology, Jiangxi Cancer Hospital, Nanchang, China.
Chunhong GuanNHC Key Laboratory of Personalized Diagnosis and Treatment for Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, Nanchang, China.
Xiaopeng XiongNHC Key Laboratory of Personalized Diagnosis and Treatment for Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, Nanchang, China.
Xiaochang GongNHC Key Laboratory of Personalized Diagnosis and Treatment for Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, Nanchang, China.
Jingao LiJiangxi Medical College, Nanchang University, Nanchang, China. lijingao@hotmail.com.

Funding

Jiangxi Province Traditional Chinese Medicine Science and Technology Plan Project 2020B0349Natural Science Foundation of Jiangxi Province 20212BAB216064Natural Science Foundation of Jiangxi Province 20224BAB206065Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences 2020-PT320-004
6 · The paper itself

Abstract

backgroundNasopharyngeal carcinoma (NPC) is associated with lymphocyte infiltration; however, the majority of research on NPC has focused on the role of T cells, with relatively little known about the roles of B cells and their subtypes. Therefore, we evaluated the prognostic value of CD20 + B cell density and B-cell subtypes along with their functional enrichment and hub genes in NPC.

methodsThe prognostic value of CD20 + B-cell density for distant metastasis-free survival (DMFS), overall survival (OS), and progression-free survival (PFS) was explored by immunohistochemistry using multivariate analysis. Transcriptomic expression data from Gene Expression Omnibus (GEO) datasets were analyzed to identify B-cell subtypes and their functional enrichment in NPC tissues. Pseudotime trajectory analysis was performed to evaluate the B-cell differentiation trajectory and hub genes were identified using Cytoscape software.

resultsPatients with NPC exhibiting a high infiltrating density of CD20

conclusionA high infiltrating density of B cells showed strong prognostic value in patients with NPC. Naïve B cells may play an important role in tumor immunity for NPC.

Indexed as

B-LymphocytesB-Lymphocyte SubsetsNasopharyngeal CarcinomaNasopharyngeal NeoplasmsFemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryLymphocytes, Tumor-InfiltratingMaleMiddle AgedPrognosisSequence Analysis, RNASingle-Cell AnalysisTranscriptomeB cellsGene expression omnibusImmune cell infiltrationNasopharyngeal carcinomaPrognosis

Identifiers

PMID40158161
PMCPMC11954199

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.