Evidence map›Paper›PMID 40158186›Full record

ArticleEnvironmental health : a global access science source2025

Maternal metabolomics linking prenatal exposure to fine particulate matter and birth weight: a cross-sectional analysis of the MADRES cohort.

Wu Chen, Chenyu Qiu, Jiayuan Hao, Jiawen Liao, Fred Lurmann, Nathan Pavlovic, Rima Habre, Dean P Jones, Theresa M Bastain, Carrie V Breton and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health : a global access science source, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wu ChenDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Chenyu QiuDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jiayuan HaoDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jiawen LiaoDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Fred LurmannSonoma Technology Inc, Petaluma, CA, USA.
Nathan PavlovicSonoma Technology Inc, Petaluma, CA, USA.
Rima HabreDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Dean P JonesDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, School of Medicine, Emory University, Atlanta, GA, USA.
Theresa M BastainDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Carrie V BretonDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Zhanghua ChenDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. zhanghuc@usc.edu.

Funding

Lifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4M
Project 3: Maternal Exposure to Environmental Hazards and Psychosocial Stressors and Postpartum Allostatic LoadP50MD015705 · NIMHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M · 2020 to 2024
$8.1M
Project 2: Environmental Exposures, Stress, and Maternal Pregnancy-Related Weight OutcomesP50ES026086 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HABRE, RIMA · 2015 to 2019
$3.7M
Metabolomic Signatures Linking Air Pollution, Obesity and DiabetesR00ES027870 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHANGHUA · 2019 to 2021
$747k
NIEHS NIH HHS P50ES026086NIEHS NIH HHS R00 ES027870NIEHS NIH HHS R00ES027870NIH HHS UH3 OD023287NIH Office of the Director UH3OD023287NIMHD NIH HHS P50 MD015705NIMHD NIH HHS P50MD015705U.S. Environmental Protection Agency 83615801
6 · The paper itself

Abstract

backgroundPrenatal exposure to air pollution has been associated with an increased risk of low birth weight. Disrupted metabolism may serve as an underlying mechanism, but the specific metabolic pathways involved remain unclear.

methodsIn the Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) study, 382 third-trimester maternal serum samples were analyzed for untargeted metabolomics using liquid chromatography with Fourier transform high-resolution mass spectrometry. Ambient concentrations of fine particulate matter (PM

resultsSecond-trimester PM

conclusionsMaternal metabolic pathways involving steroid metabolism, oxidative stress and inflammation, vitamin metabolism, and DNA damage may link prenatal PM

Indexed as

Air PollutantsBirth WeightMaternal ExposureParticulate MatterAdultCohort StudiesCross-Sectional StudiesFemaleHumansInfant, Low Birth WeightInfant, NewbornMetabolomicsNitrogen DioxideOzonePregnancyPregnancy Trimester, ThirdAir PollutantsNitrogen DioxideOzoneParticulate MatterFine particulate matterLow birth weightMaternal obesityMetabolomicsPrenatal air pollution exposure

Identifiers

PMID40158186
PMCPMC11954335

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.