Evidence map›Paper›PMID 40159449›Full record

Trial reportExperimental physiology2025

Effects of acute selective cyclooxygenase-2 inhibition on skeletal muscle microvascular oxygenation and exercise tolerance.

Michael D Belbis, Michael J Holmes, Joseph Yao, Christopher W Kinnick, Christopher K Kargl, Carly Day, Nicole L Noel, Timothy P Gavin, Bruno T Roseguini, Daniel M Hirai

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Experimental physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michael D BelbisDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.ORCID https://orcid.org/0000-0002-3312-2085
Michael J HolmesDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.
Joseph YaoDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.
Christopher W KinnickDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.
Christopher K KarglDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.ORCID https://orcid.org/0000-0002-2391-8274
Carly DayAthletics Department, Purdue University, West Lafayette, Indiana, USA.
Nicole L NoelDepartment of Pharmacy Practice, Purdue University, West Lafayette, Indiana, USA.
Timothy P GavinDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.ORCID https://orcid.org/0000-0003-0679-7076
Bruno T RoseguiniDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.
Daniel M HiraiDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.ORCID https://orcid.org/0000-0002-7861-637X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cyclooxygenase (COX) pathway regulates vascular tone and, therefore, local O

Indexed as

Cyclooxygenase 2 InhibitorsExercise ToleranceMicrovesselsMuscle, SkeletalAdultCelecoxibCross-Over StudiesCyclooxygenase 2Double-Blind MethodEpoprostenolExerciseFemaleHeart RateHumansMaleMicrocirculationCelecoxibCyclooxygenase 2Cyclooxygenase 2 InhibitorsEpoprostenolOxygenCOX‐2microcirculationNIRSoxygen uptake kineticspulmonary

Identifiers

PMID40159449
PMCPMC12665951

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.