Evidence map›Paper›PMID 40159591›Full record

ReviewBiogerontology2025

Redox modulatory role of DJ-1 in Parkinson's disease.

Qamar A Alshammari

Abstract readReview
PubMed Publisher
In one paragraph

Review in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. DJ-1 Serves as a Central Regulator of Diabetes Complications.Current issues in molecular biology · 2025
    Review
  7. Article
  8. Nano-structured strategies in combatting neurodegeneration.Frontiers in bioengineering and biotechnology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Qamar A AlshammariDepartment of Pharmacology and Toxicology, College of Pharmacy, Northern Border University, Rafha, Saudi Arabia. qamar.alshammari@nbu.edu.sa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In particular, oxidative stress, generated by excessive reactive oxygen species (ROS), plays a major role in the neurodegenerative component of Parkinson's disease (PD) in aged neurons. DJ-1 (PARK7) is a key factor for maintaining redox homeostasis and modulation of mitochondrial function to preserve the cellular survival pathways. DJ-1 also plays a role in redox signaling independently of its antioxidant capacity by preventing the redox chain disulfide formation and stabilizing the master regulator of cellular antioxidant defense, Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2). In the DJ-1 or Nrf2 axis, expression of key antioxidant enzymes (glutathione peroxidase (GPx), superoxide dismutase (SOD), and heme oxygenase-1 (HO-1) in response to oxidative stress is increased, and decreased neuronal damage resulting from oxidative stress is achieved. It has been demonstrated that DJ-1 functions as an oxidative stress sensor, and mutations like L166P cause loss of antioxidant activity and increased Reactive Oxygen Species (ROS) accumulation with subsequent mitochondrial dysfunction in dopaminergic neurons. The highly conserved cysteine residue at position 106 (Cys106) of DJ-1 becomes stepwise oxidized (Cys-SOH → Cys-SO₂H → Cys-SO

Indexed as

Parkinson DiseaseProtein Deglycase DJ-1AnimalsHumansOxidation-ReductionOxidative StressReactive Oxygen SpeciesPARK7 protein, humanProtein Deglycase DJ-1Reactive Oxygen SpeciesAgingDJ-1MitochondriaNeuroinflammationOxidative stressParkinson’s disease

Identifiers

PMID40159591

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.