Evidence mapPaperPMID 40159960Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[

Yanyan Dong, Kejing Zhang, Jun Chu, Quangen Chu

Abstract readEnglish Abstract
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yanyan DongSchool of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230012, China.
Kejing ZhangSchool of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230012, China.
Jun ChuSchool of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230012, China.
Quangen ChuSchool of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230012, China.

Funding

National Natural Science Foundation of China 81774189
6 · The paper itself

Abstract

objectivesTo investigate the effect of

methodsPrimary RGECs were isolated and cultured using sequential sieving combined with collagenase digestion, followed by identification using immunofluorescence assay for factor VIII. High glucose medium was used to induce RGECs to simulate a diabetic environment, and the effects of

resultsCompared with the control cells, the HG-exposed RGECs showed significantly reduced autophagic fluorescence intensity, decreased Beclin-1 mRNA expression, increased p62 mRNA expression, downregulated Beclin-1 protein and LC3-II/I ratio, and upregulated p62, p-PI3K, p-Akt, and p-mTOR protein levels.

conclusions

Indexed as

AutophagyDrugs, Chinese HerbalEndothelial CellsAnimalsCells, CulturedGlucoseKidney GlomerulusPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleySignal TransductionTOR Serine-Threonine KinasesDrugs, Chinese HerbalGlucosemTOR protein, ratPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinasesautophagydiabetic nephropathyDidang decoctionglomerular endothelial cellsPI3K/Akt/mTOR signaling pathway

Identifiers

PMID40159960
PMCPMC11955890

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.