ArticleFuture science OA2025
Oxidative markers and SOD variant: predictors of autism severity and susceptibility.
Article in Future science OA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- Article
- Redox System Dysfunction as a Key Mechanism in Autism Spectrum Disorder Pathogenesis.International journal of molecular sciences · 2025Review
- Effect of valproic acid administration on motor coordination and sensory function inOpen veterinary journal · 2025Article
- Effects of dapagliflozin on podocyte damage and oxidative stress in patients with diabetic nephropathy.Diabetology & metabolic syndrome · 2025Article
- The effects of heavy smoking on oxidative stress, inflammatory biomarkers, vascular dysfunction, and hematological indices.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study examines the relationship between oxidative stress, anti-oxidative markers, and the Ala16Val SOD2 polymorphism in children with autism spectrum disorder (ASD) to better understand ASD severity and susceptibility. MATERIAL AND
methodsThe study included 80 children (40 with ASD and 40 controls) from Erbil City, Iraq.
resultsSerum antioxidant markers, such as superoxide dismutase (SOD) and glutathione peroxidase (GPX), were significantly lower in ASD patients compared to controls (P = 0.036 and P < 0.001, respectively), while markers of oxidative damage, including malondialdehyde (MDA), nitric oxide (NO), and cytochrome C, were significantly elevated (P < 0.001). Regression analysis revealed reduced SOD and GPX activities were strongly associated with increased autism severity, as measured by the childhood autism rating scale (CARS), while elevated NO and cytochrome C levels also correlated positively with higher CARS scores. Although the Ala16Val SOD polymorphism was not significantly associated with ASD risk, logistic regression showed no connection between SOD genotypes and serum SOD levels.
conclusionThese findings suggest oxidative stress and impaired antioxidant defense play critical roles in ASD severity.
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Registered trials
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