Evidence map›Paper›PMID 40160579›Full record

ReviewReviews in cardiovascular medicine2025

Arrhythmic Risk Stratification and Sudden Cardiac Death Prevention in Duchenne Muscular Dystrophy: A Critical Appraisal.

Domenico D'Amario, Alessandra Arcudi, Maria Lucia Narducci, Valeria Novelli, Francesco Canonico, Alessandro Parodi, Gabriele Dell'Era, Marco Di Francesco, Renzo Laborante, Josip Andelo Borovac and 9 more

Abstract readReview
In one paragraph

Review in Reviews in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Domenico D'AmarioDepartment of Translational Medicine, University of Eastern Piedmont, 28100 Novara, Italy.ORCID https://orcid.org/0000-0003-3774-8330
Alessandra ArcudiThoraco-Cardio-Vascular Department, Azienda Ospedaliero-Universitaria Maggiore della Carità, 28100 Novara, Italy.
Maria Lucia NarducciDepartment of Cardiovascular Science, Fondazione Policlinico Agostino Gemelli IRCCS, 00168 Rome, Italy.
Valeria NovelliDepartment of Cardiac Surgery, Centro Cardiologico Monzino-IRCCS, 20138 Milan, Italy.
Francesco CanonicoThoraco-Cardio-Vascular Department, Azienda Ospedaliero-Universitaria Maggiore della Carità, 28100 Novara, Italy.
Alessandro ParodiDepartment of Translational Medicine, University of Eastern Piedmont, 28100 Novara, Italy.ORCID https://orcid.org/0000-0002-5086-8233
Gabriele Dell'EraDepartment of Translational Medicine, University of Eastern Piedmont, 28100 Novara, Italy.
Marco Di FrancescoDepartment of Cardiovascular Science, Catholic University of the Sacred Heart, 00168 Rome, Italy.
Renzo LaboranteDepartment of Cardiovascular Science, Fondazione Policlinico Agostino Gemelli IRCCS, 00168 Rome, Italy.
Josip Andelo BorovacClinic for Heart and Vascular Diseases, University Hospital of Split, 21000 Split, Croatia.
Mattia GalliMaria Cecilia Hospital, GVM Care and Research, 48033 Cotignola, Italy.
Eugenio Maria MercuriDepartment of Cardiovascular Science, Fondazione Policlinico Agostino Gemelli IRCCS, 00168 Rome, Italy.
Giuseppe VergaroFondazione Toscana G. Monasterio, 56126 Pisa, Italy.
Antonio Dello RussoCardiology and Arrhythmology Clinic, University Hospital "Ospedali Riuniti Umberto I-Lancisi-Salesi", 60126 Ancona, Italy.
Anthea Tonia D'AmicoDepartment of Translational Medicine, University of Eastern Piedmont, 28100 Novara, Italy.
Antonio BisignaniCenter of Excellence in Cardiovascular Sciences, Ospedale Isola Tiberina-Gemelli Isola, 00153 Rome, Italy.
Rachele AdorisioAdvanced Cardiovascular Therapy Unit, Bambino Gesù Pediatric Hospital and Research Institute, 00165, Rome, Italy.
Giulio PompilioDepartment of Cardiac Surgery, Centro Cardiologico Monzino-IRCCS, 20138 Milan, Italy.
Giuseppe PattiDepartment of Translational Medicine, University of Eastern Piedmont, 28100 Novara, Italy.ORCID https://orcid.org/0000-0002-5404-3968

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a genetic progressive neuromuscular disorder characterized by early-onset proximal muscle weakness and significant long-term pulmonary and cardiac involvement. Due to the early pharmacological treatments and the wider adoption of non-invasive ventilation, life expectancy has significantly increased in recent years, highlighting the relevance of DMD-related cardiomyopathy and fatal arrhythmias, especially in the late stage of the disease. Current guideline-derived evaluation of sudden cardiac death (SCD) in DMD lacks accuracy, leading to inadequate arrhythmic risk stratification and jeopardized SCD prevention strategies. This review aims to outline these critical issues, proposing an integrative approach encompassing manifold tools such as an imaging-derived systematic and comprehensive evaluation (speckle-tracking echocardiography and magnetic resonance imaging), the electrophysiological study, the 3-dimensional electroanatomic mapping, and a multidimensional clinical examination. This approach might lead to more personalized management along with an effective arrhythmia-prevention strategy aiming to balance clinical care goals, patient expectations, and ethical considerations.

Indexed as

arrhythmic risk stratificationdilated cardiomyopathyDuchenne muscular dystrophyimplantable cardioverter defibrillatorsudden cardiac death prevention

Identifiers

PMID40160579
PMCPMC11951492

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.