ArticleACS omega2025
Design and Synthesis of Novel Di-Boronic Acid-Based Chemical Glucose Sensors.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Goldilocks boronic esters: optimized properties through understanding hydrolysis kinetics.Chemical science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemical-based fluorescent sensors with the capability of long-term stability and low cost are promising agents in clinical diagnosis and medical research. Measuring glucose levels inside cells and their surroundings provides insight into cellular metabolic homeostasis and may be employed as an indicator for potential pathological conditions. Anthracene-based diboronic acid (BA) derivatives offer a reversible and covalent binding mechanism for glucose recognition, which enables robust and continuous glucose monitoring. To improve its poor solubility and biological applicability, a diboronic acid chemical structure design was explored. To date, several anthracene-based ortho-amino methylphenyl boronic acid glucose-sensors have been developed. Most recently, the structure of Mc-CDBA (((((2-(methoxycarbonyl) anthracene-9,10-diyl) bis (methylene)) bis(methylazanediyl)) bis(methylene)) bis(4-cyano-2,1-phenylene)) diboronic acid was disclosed. Mc-CDBA exhibits suitable water-solubility and sensitivity toward glucose, with limited modification sites and suitability to extra-cellular applications. Here, we present a palette of Mc-CDBA derivatives: carboxylic (BA), amid (BA 5) and acryl (BA 21)-based Mc-CDBA sensors for extra- and intracellular glucose monitoring, respectively. The developed chemical glucose sensors were designed to obtain a final product with fewer synthetic steps, allowing easier scale-up capacity. Moreover, we showed that ortho-amino site modifications do not interfere with the sensor activity, allowing alternative water solubility solutions without chemically modifying the chromophore/aromatic subunits within the molecule. Among these probes, we also developed an extracellular hydrogel-embedded sensor (BA 21) to monitor extracellular glucose levels under persistent solution flow, a feature that is lacking in other glucose sensors. The synthesized derivatives could serve as diverse fluorescent sensors for glucose monitoring in medical applications.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.