ArticleACS omega2025
Enhanced Osteogenic Differentiation of hMSCs Using BMP@ZIF-8-Loaded GelMA Nanocomposite Hydrogels with Controlled BMP-2 Release.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Light-Curable Methacrylated Carboxymethyl Chitosan Hydrogel Incorporating Bone Morphogenic Protein-2-Immobilized Bioactive Glass for Spinal Bone Regeneration.Biomaterials research · 2026Article
- Visible-light-triggered BMP-2 release from enzymatically crosslinked marine collagen-alginate hydrogel blends enhances osteogenesis in dental pulp stem cells.Frontiers in physiology · 2026Article
- Bone Morphogenetic Proteins in Orthopedics: A Bibliometric Analysis.Indian journal of orthopaedics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogels are highly versatile materials with immense potential for tissue engineering and regenerative medicine owing to their biocompatibility, tunable mechanical properties, and ability to mimic the natural extracellular matrix. Their 3D porous structure allows for the encapsulation and delivery of bioactive molecules, making them ideal candidates for drug delivery systems. In tissue repair, particularly for bone regeneration, hydrogels can serve as carriers that release therapeutic agents in a controlled manner, thus enhancing the healing process. Zeolitic Imidazolate Framework-8 (ZIF-8) nanoparticles and recombinant human Bone Morphogenetic Protein (rhBMP-2) molecules were incorporated solely (ZIF@GelMA) or in association (BMP@ZIF@GelMA) into gelatin modified by a methacryloyl hydrogel (GelMA) to investigate its physical and osteogenic properties. Hydrogels were characterized by Scanning Electron Microscopy and rheological tests. We analyzed hydrogel degradation and the BSA release profile of BMP@ZIF@GelMA samples throughout 0, 1, 3, 7, 14, and 28 days. Cell adhesion and bone formation markers were analyzed for hydrogel-encapsulated human dental pulp cells by using immunocytochemistry and molecular analysis. ZIF@GelMA and BMP@ZIF@GelMA exhibited a porous and viscoelastic structure with increased storage modulus when rhBMP2 was present. BSA@ZIF@GelMA showed a balanced degradation rate and a controlled release of BSA. The ZIF@GelMA upregulated the expression of cell adhesion and bone formation genes, and when BMP-2 was introduced, the levels of markers were remarkably elevated. BMP@ZIF@GelMA hydrogel presents several favorable factors to promote cellular adhesion and bone regeneration, thus encouraging further prospects for advanced therapeutic applications in tissue repair.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.