ReviewJournal of orthopaedic translation2025
Identification and function of periosteal skeletal stem cells in skeletal development, homeostasis, and disease.
Review in Journal of orthopaedic translation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Talin1 loss activates DRG neurons to accelerate bone remodeling and fracture healing in mice.Journal of orthopaedic translation · 2026Article
- Mechanobiological Implications of Low-Young's Modulus TiNbSn Alloy Plates for Fracture Fixation: A Focused Review.Medical sciences (Basel, Switzerland) · 2026Review
- Self-assembled hybrid hydrogel microspheres create a bone marrow-mimicking niche for bone regeneration.Bioactive materials · 2025Article
- Integrative analysis reveals synergistic regulation of Sp7 by BRD9 and Wnt/β-catenin signaling during osteogenic differentiation.Communications biology · 2025Article
- NLRP3 inflammasome impairs fracture repair in Rheumatoid arthritis through RhoA/Rac1-IL1β axis-mediated suppression of osteoblast differentiation.Journal of orthopaedic translation · 2025Article
- Tackling musculoskeletal disorders in an aging world: Advances in orthopaedic translational research.Journal of orthopaedic translation · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Periosteum-resident skeletal stem cells (SSCs) are essential for the growth, maintenance, and repair of the skeletal system. These cells exhibit self-renewal ability and clonal pluripotency. Compared to the diverse bone marrow mesenchymal stem cells (BMSCs), periosteal skeletal stem cells (P-SSCs) represent a purified stem cell population and are preferable for bone tissue engineering. Methods: This review covers the histological structure of the periosteum, process of isolating and characterising P-SSCs, and spatiotemporal distribution and characteristics of P-SSCs from different lineages. Additionally, the roles of P-SSCs in bone injury, disease, and periosteal niche regulation are discussed. Results: Intramembrane and intraconal ossification of P-SSCs exhibits favourable therapeutic potential. Osteogenesis using P-SSCs is an ideal process for bone repair. Conclusions: P-SSCs are vital for bone formation, maintenance, and repair. P-SSCs are essential components of the periosteal microenvironment. Therefore, it is essential to investigate their critical clinical applications and translational functions. By targeting and inducing endogenous stem cells, the in situ repair of bone defects can be facilitated, leading to the development of more effective novel therapies. The translational potential of this article: To enhance our understanding of the function of P-SSCs in bone repair and skeleton-related diseases, it is imperative to elucidate the current research status of P-SSCs and ascertain the prospective trajectory for their advancement and refinement in bone tissue engineering. P-SSCs are expected to play an expanded role in treating bone abnormalities, leading to the optimisation of bone tissue treatment.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.