Evidence map›Paper›PMID 40161597›Full record

ArticlebioRxiv : the preprint server for biology2025

Glial Contribution to the Pathogenesis of Post-Operative Delirium Revealed by Multi-omic Analysis of Brain Tissue from Neurosurgery Patients.

Takaya Ishii, Tao Wang, Kazuki Shibata, Shota Nishitani, Takehiko Yamanashi, Nadia E Wahba, Tomoteru Seki, Kaitlyn J Thompson, Kyosuke Yamanishi, Tsuyoshi Nishiguchi and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Takaya IshiiDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Tao WangDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Kazuki ShibataDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Shota NishitaniDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Takehiko YamanashiFaculty of Medicine, Department of Neuropsychiatry, Tottori University, Yonago, Tottori, Japan.
Nadia E WahbaDepartment of Psychiatry, Oregon Health and Science University, School of Medicine, Portland, Oregon, USA.
Tomoteru SekiDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Kaitlyn J ThompsonUniversity of Nebraska Medical Center, Omaha, Nebraska, USA.
Kyosuke YamanishiDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Tsuyoshi NishiguchiDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.ORCID 0000-0002-8230-8804
Akiyoshi ShimuraDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Bun AoyamaDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Nipun GorantlaDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Nathan J PhuongDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Hieu D NguyenDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Therese A SantiagoDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Yoshitaka NishizawaDepartment of Psychiatry, Osaka Medical and Pharmaceutical University School of Medicine, Osaka, Japan.
Takaaki NagaoDepartment of Neurosurgery (Sakura), Toho University School of Medicine Faculty of Medicine, Sakura, Chiba, Japan.
Mathew A HowardDepartment of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Hiroto KawasakiDepartment of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Kyosuke HinoRegenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd., Osaka, Osaka, Japan.
Atsushi IkedaRegenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd., Osaka, Osaka, Japan.
Michael P SnyderDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Gen ShinozakiDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.

Funding

Identification of Epigenetics Correlates between Brain and Peripheral TissuesR01MH119165 · NIMH · STANFORD UNIVERSITY · PI Gen Shinozaki · 2022 to 2024
$1.8M
Epigenetics Biomarker of Post Operative Delirium and Long Term Cognitive Decline among Elderly Dementia PatientsR01AG084710 · STANFORD UNIVERSITY · 2025 to 2025
$1.1M
NIA NIH HHS R01 AG084710NIMH NIH HHS R01 MH119165
6 · The paper itself

Abstract

Post-operative delirium (POD) is a common complication after surgery especially in elderly patients, characterized by acute disturbances in consciousness and cognition, which negatively impacts long-term outcomes. Effective treatments remain elusive due to the unclear pathophysiology of POD. To address the knowledge gap, we investigated DNA methylation profiles and gene expression changes in brain cells from POD and non-POD patients who underwent brain resection surgery for medication refractory epilepsy. DNA methylation analysis revealed alteration in epigenetic status of immune and inflammation-related genes. Single-nucleus RNA sequencing (snRNAseq) identified POD-specific glial cell alterations, particularly in microglia, where neuroinflammation was strongly enhanced, consistent with epigenetic findings. Astrocytes exhibited changes in synapse-related functions and migration. Furthermore, downstream analysis indicated similarities between POD-associated glial cell states and pathologies such as encephalitis and dementia. Overall, this study-the first multi-omics analysis of brain tissue from POD patients-provides direct evidence of glial cell contributions to POD pathogenesis, and highlights potential therapeutic targets.

Identifiers

PMID40161597
PMCPMC11952519

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.