Evidence map›Paper›PMID 40161696›Full record

ArticlebioRxiv : the preprint server for biology2025

Human Stress Response Specificity through Bioresonance Selectivity.

Michael Worcester, Shayan Nejad, Devin O'Donnell, Surya Arian, Pratyasha Mishra, Arya Eimagh Naeini, Siyu Li, Kevin Yang, Aisa Anbir, Matthew Guevara and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Michael WorcesterDepartment of Physics and Astronomy, University of California, Riverside; Riverside, CA, 92521, USA.
Shayan NejadDepartment of Physics and Astronomy, University of California, Riverside; Riverside, CA, 92521, USA.
Devin O'DonnellBiophysics Program, University of California, Riverside; Riverside, CA, 92521, USA.
Surya ArianMicrobiology Program, University of California, Riverside; Riverside, CA, 92521, USA.
Pratyasha MishraBiophysics Program, University of California, Riverside; Riverside, CA, 92521, USA.
Arya Eimagh NaeiniDepartment of Physics and Astronomy, University of California, Riverside; Riverside, CA, 92521, USA.
Siyu LiDepartment of Physics and Astronomy, California State Polytechnic University, Pomona; Pomona, CA, 91768, USA.
Kevin YangDepartment of Physics and Astronomy, University of California, Riverside; Riverside, CA, 92521, USA.
Aisa AnbirBiophysics Program, University of California, Riverside; Riverside, CA, 92521, USA.
Matthew GuevaraDepartment of Biochemistry, University of California, Riverside; Riverside, CA, 92521, USA.
Nina Y YuanDivision of Biomedical Sciences, School of Medicine, University of California, Riverside; Riverside, CA, 92521, USA.
Seán O'LearyDepartment of Biochemistry, University of California, Riverside; Riverside, CA, 92521, USA.
Marcus KaulDivision of Biomedical Sciences, School of Medicine, University of California, Riverside; Riverside, CA, 92521, USA.
Roya ZandiDepartment of Physics and Astronomy, University of California, Riverside; Riverside, CA, 92521, USA.ORCID 0000-0001-8769-0419
Thomas E KuhlmanDepartment of Physics and Astronomy, University of California, Riverside; Riverside, CA, 92521, USA.ORCID 0000-0002-4009-5601

Funding

Methamphetamine Effect on HIV PersistenceR01DA052209 · NIDA · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI KAUL, MARCUS · 2020 to 2024
$3.2M
NIDA NIH HHS R01 DA052209
6 · The paper itself

Abstract

In all eukaryotes, the mitogen activated protein kinase (MAPK) cascade, a multilayered interconnected network of enzymes, connects external stimuli to gene regulation, dictating cellular fate. However, mechanisms for encoding information in this complex, fluctuating network to activate specific responses remain elusive. Here, we demonstrate that the central human stress regulator protein p38 MAPK encodes information regarding experienced stresses as different frequency oscillations of its activation state. These oscillations are used to drive specific responses through frequency-dependent resonance of oscillating biochemical phosphorylation reactions between p38 and downstream targets. These interactions closely mirror those of electronic alternating current (AC) circuits and their components, providing a unique framework through which to understand signal transduction in the MAPK cascade. Finally, we demonstrate how this understanding of bioresonance allows us to induce specific genetic responses simply by exposing cells to sugar to force activation state oscillations of p38 at predetermined frequencies.

Identifiers

PMID40161696
PMCPMC11952327

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.