Evidence map›Paper›PMID 40161726›Full record

ArticlebioRxiv : the preprint server for biology2025

A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase.

Annika Engel, Viktoria Wagner, Oliver Hahn, Aulden G Foltz, Micaiah Atkins, Amila Beganovic, Ian H Guldner, Nannan Lu, Aryaman Saksena, Ulrike Fischer and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Annika EngelClinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.ORCID 0000-0001-5570-3115
Viktoria WagnerClinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.ORCID 0000-0002-1957-0658
Oliver HahnDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0001-9015-4545
Aulden G FoltzDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.
Micaiah AtkinsDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0003-0068-5217
Amila BeganovicClinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.
Ian H GuldnerDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0001-8715-136X
Nannan LuDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0003-0905-8199
Aryaman SaksenaDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.ORCID 0009-0002-1341-9428
Ulrike FischerDepartment of Human Genetics, Saarland University, 66421 Homburg/Saar, Germany.ORCID 0000-0002-7808-9565
Nicole LudwigDepartment of Human Genetics, Saarland University, 66421 Homburg/Saar, Germany.ORCID 0000-0003-4703-7567
Eckart MeeseDepartment of Human Genetics, Saarland University, 66421 Homburg/Saar, Germany.
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0001-5893-0831
Andreas KellerClinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.ORCID 0000-0002-5361-0895

Funding

Studying Neuronal Proteostasis During Aging and AD with Novel Protein Tagging ToolsK99AG088304 · NIA · STANFORD UNIVERSITY · PI GULDNER, IAN HUNTER · 2024 to 2025
$262k
NIA NIH HHS K99 AG088304
6 · The paper itself

Abstract

An in-depth understanding of the molecular processes composing aging is crucial to develop therapeutic approaches that decrease aging as a key risk factor for cognitive decline. Herein, we present a spatio-temporal brain atlas (15 different regions) of microRNA (miRNA) expression across the mouse lifespan (7 time points) and two aging interventions composed of 1009 samples. MiRNAs are promising therapeutic targets, as they silence genes by complementary base-pair binding of messenger RNAs and are known to mediate aging speed. We first established sex- and brain-region-specific miRNA expression patterns in young adult samples. Then we focused on sex-dependent and independent brain-region-specific miRNA expression changes during aging. The corpus callosum in males and the choroid plexus in females exhibited strong sex-specific age-related signatures. In this work, we identified three sex-independent brain aging miRNAs (miR-146a-5p, miR-155-5p and miR-5100). We showed for miR-155-5p that these expression changes are driven by aging microglia. MiR-155-5p targets mTOR signaling pathway components and other cellular communication pathways and is hence a promising therapeutic target.

Indexed as

AgingmiRNAtranscriptional regulation

Identifiers

PMID40161726
PMCPMC11952541

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.