Evidence map›Paper›PMID 40161815›Full record

ArticlebioRxiv : the preprint server for biology2025

Probing the substrate binding-induced conformational change of a ZIP metal transporter using a sandwich ELISA.

Yao Zhang, Ryan Hu, Min Su, Jian Hu

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Yao ZhangDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824.
Ryan HuDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824.
Min SuElectron Microscopy Core, University of Missouri, MO 65211.
Jian HuDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824.

Funding

Transport, substrate specificity and regulation mechanisms of the ZIP transition metal transportersR35GM140931 · NIGMS · MICHIGAN STATE UNIVERSITY · PI HU, JIAN · 2021 to 2025
$1.7M
NIGMS NIH HHS R35 GM140931
6 · The paper itself

Abstract

Zrt-/Irt-like proteins (ZIPs), a family of divalent metal transporters, are crucial for maintaining the homeostasis of zinc, an essential trace element involved in numerous biological processes. While extensive research on the prototypical ZIP from

Indexed as

conformationcysteine accessibilityELISAtransporterzincZIP

Identifiers

PMID40161815
PMCPMC11952358

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.