ArticleJournal of inflammation research2025
Dysregulation of lncRNA GATA3-AS1 is Involved in the Pathogenesis of Pulpitis by the Regulation of miR-17-3p.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Molecular mechanism by which mir-153-3p attenuates pulpitis in human deciduous teeth via PTEN-targeted suppression of inflammation and oxidative stress.Odontology · 2026Article
- Long non-coding RNA FOXD2-AS1 promotes inflammation but suppresses osteogenesis in pulpitis via miR-338-3p/THBS1 axis.Odontology · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: When the pulp is inflamed or injured, cell morphology, gene expression, and synaptic connections change occur in the medullary dorsal horn, causing inflammation pain and formatting the pulpitis pain. To examine the impact of lncRNA GATA3-AS1 regulation of miR-17-3p on bioactivity and inflammation of lipopolysaccharides (LPS)-stimulated human dental pulp stem cells (hDPSCs). Patients and Methods: The GATA3-AS1 expression in serum samples from patients with pulpitis, dental caries, and healthy control was examined using RT-qPCR. The GATA3-AS1 expression was verified using the GSE198359 dataset. hDPSCs were exposed to LPS to mimic in vitro pulpitis model. The viability and apoptotic rates of hDPSCs were determined by CCK-8 method and Flow cytometric analysis. The inflammatory cytokines levels were quantified using ELISA-based approach. A SOD assay kit was utilized to measure the activity of SOD. Bioinformatic analysis and dual-luciferase reporter assay were performed to explore the interaction between GATA3-AS1 and miR-17-3p, along with the potential mechanism. Results: Serum and tissue GATA3-AS1 levels were elevated in patients with pulpitis. Silencing GATA3-AS1 overturned the LPS stimulation inhibited viability and promoted apoptosis, inflammation, and oxidative stress in hDPSCs. GATA3-AS1 could target miR-17-3p, and miR-17-3p downregulation reversed silencing GATA3-AS1-mediated effects in LPS-induced hDPSCs. The GATA3-AS1-miR-17-3p axis might mediate the progression of pulpitis by many potential pathways, such as the PI3K-Akt signaling pathway and MAPK signaling pathway. Conclusion: GATA3-AS1 knockdown might have a protective effect on bioactivity, LPS-triggered inflammation, and damage in hDPSCs by regulating miR-17-3p, which might be a promising target for the treatment of pulpitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.