Evidence map›Paper›PMID 40162272›Full record

ArticlemedRxiv : the preprint server for health sciences2025

IgA-driven neutrophil activation underlies post-Zika severe dengue disease in humans.

Jaime A Cardona-Ospina, Vicky Roy, Dorca E Marcano-Jiménez, Sandra Bos, Elias Duarte, José V Zambrana, Agamjot Bal, Antonio Gregorio Dias, Julia Zhiteneva, Julia Huffaker and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Jaime A Cardona-OspinaDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA.ORCID 0000-0003-3996-2293
Vicky RoyRagon Institute of MGH, MIT, and Harvard, Cambridge, MA.ORCID 0000-0002-5064-1098
Dorca E Marcano-JiménezDepartment of Basic Sciences, Ponce Health Sciences University and Ponce Research Institute, Ponce, Puerto Rico.
Sandra BosDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA.ORCID 0000-0001-5036-0336
Elias DuarteDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA.
José V ZambranaSustainable Sciences Institute, Managua, Nicaragua.ORCID 0000-0003-0107-6173
Agamjot BalDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA.
Antonio Gregorio DiasDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA.ORCID 0000-0003-4392-4206
Julia ZhitenevaRagon Institute of MGH, MIT, and Harvard, Cambridge, MA.
Julia HuffakerDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA.
Carlos MontenegroSustainable Sciences Institute, Managua, Nicaragua.
Guillermina KuanSustainable Sciences Institute, Managua, Nicaragua.
Marcos J Ramos-BenitezDepartment of Basic Sciences, Ponce Health Sciences University and Ponce Research Institute, Ponce, Puerto Rico.ORCID 0000-0001-9445-3294
Angel BalmasedaSustainable Sciences Institute, Managua, Nicaragua.
Galit AlterRagon Institute of MGH, MIT, and Harvard, Cambridge, MA.
Eva HarrisDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA.ORCID 0000-0002-7238-4037

Funding

Project 3 - Ex vivo immune profiling of dengue viruses and vaccinesU19AI118610 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MERAD, MIRIAM · 2015 to 2021
$46.6M
The Role of Midbrain to Prelimbic Cortex Glutamatergic projections in Stress-induced Drug SeekingU54MD007579 · NIMHD · PONCE SCHOOL OF MEDICINE · PI Emmanuel Antonio Cruz, Kenira J Thompson · 2019 to 2026
$35.9M
T Cell Responses Following DENV Natural Infections and Live-Attenuated Dengue Virus VaccinationP01AI106695 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Daniela Weiskopf · 2015 to 2026
$34.1M
Tracking and Evaluation CoreU54GM133807 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI PORTER, JAMES T. · 2020 to 2024
$17.7M
Living in the post-Zika world: Impact of interactions between dengue and Zika viruses on diagnostics, antibody dynamics, and correlates of disease riskU01AI153416 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARRIS, EVA · 2021 to 2025
$4.9M
Epidemiological, Clinical & Immunological Studies of Zika, dengue and chikungunyaR01AI099631 · NIAID · SUSTAINABLE SCIENCES INSTITUTE · PI BALMASEDA, ANGEL LAZARO · 2012 to 2021
$1.8M
NIAID NIH HHS P01 AI106695NIAID NIH HHS R01 AI099631NIAID NIH HHS U01 AI153416NIAID NIH HHS U19 AI118610NIGMS NIH HHS U54 GM133807NIMHD NIH HHS U54 MD007579
6 · The paper itself

Abstract

The four dengue virus serotypes (DENV1-4) and the related Zika flavivirus (ZIKV) are major public health concerns worldwide. Primary immunity against ZIKV increases the risk of a subsequent severe DENV2 infection, presenting a significant challenge for developing safe and effective ZIKV vaccines. However, the mechanisms driving this phenomenon remain unclear. Leveraging our long-standing Pediatric Dengue Cohort Study in Nicaragua, we show that serum anti-NS1 IgA antibodies elicited after a primary ZIKV infection drive neutrophil activation and correlate with increased risk of subsequent severe DENV2 disease. Depletion experiments combined with e

Identifiers

PMID40162272
PMCPMC11952487

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.