Evidence map›Paper›PMID 40162285›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Factors associated with age at tau pathology onset and time from tau onset to dementia.

Margo B Heston, Jordan P Teague, Karly A Cody, Yuetiva Deming, Elena Ruiz de Chavez, Jacob Morse, Nathaniel A Chin, Corinne D Engelman, Richard J Chappell, Rebecca E Langhough and 5 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Margo B HestonWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC 2420, Madison, WI 53792-2420.ORCID 0000-0002-0980-2275
Jordan P TeagueWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC 2420, Madison, WI 53792-2420.ORCID 0000-0001-6688-6949
Karly A CodyDepartment of Neurology and Neurological Sciences, Stanford University Center for Academic Medicine, 453 Quarry Road, Palo Alto, CA 94304.ORCID 0000-0001-5996-2560
Yuetiva DemingWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC 2420, Madison, WI 53792-2420.ORCID 0000-0001-7512-5703
Elena Ruiz de ChavezWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC 2420, Madison, WI 53792-2420.
Jacob MorseWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC 2420, Madison, WI 53792-2420.ORCID 0009-0004-1007-2531
Nathaniel A ChinWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC 2420, Madison, WI 53792-2420.ORCID 0000-0001-8008-9356
Corinne D EngelmanWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC 2420, Madison, WI 53792-2420.ORCID 0000-0003-4750-5607
Richard J ChappellWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC 2420, Madison, WI 53792-2420.
Rebecca E LanghoughWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC 2420, Madison, WI 53792-2420.ORCID 0000-0003-0025-744X
Carey E GleasonWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC 2420, Madison, WI 53792-2420.ORCID 0000-0001-6210-4671
Lindsay R ClarkWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC 2420, Madison, WI 53792-2420.ORCID 0000-0003-4837-7627
Megan L ZuelsdorffWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC 2420, Madison, WI 53792-2420.ORCID 0000-0002-9632-475X
Tobey J BetthauserWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC 2420, Madison, WI 53792-2420.ORCID 0000-0001-8856-1352
Alzheimer’s Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Barbara Brigitta Bendlin · 2019 to 2026
$34.5M
African Americans Fighting Alzheimer’s in Midlife (AA-FAIM)R01AG054059 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAREY E GLEASON · 2016 to 2026
$15.3M
Multi-cohort study of factors that influence Alzheimer's disease biomarker and dementia timingR01AG080766 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI TOBEY JAMES BETTHAUSER · 2023 to 2026
$3.1M
NIA NIH HHS P30 AG062715NIA NIH HHS R01 AG054059NIA NIH HHS R01 AG080766NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

introductionElevated tau is temporally proximal to dementia onset but less is known about factors influencing T+ onset age and time to dementia following T+ in Alzheimer's disease. We used sampled iterative localized approximation (SILA) estimated T+ onset age (ETOA) to investigate factors associated with T+ age and time from T+ to dementia onset in ADNI.

methodsUsing SILA-estimated A+ and T+ onset ages derived from

resultsHigher amyloid, DISCUSSION: This work highlights the prognostic value of ETOA and the need to better characterize factors contributing to ETOA and dementia onset in AD.

Indexed as

Alzheimer’s diseaseamyloid betaAPOEdementia riskestimated tau onset ageliteracy exposureSILAsocial determinants of healthtemporal modeling

Identifiers

PMID40162285
PMCPMC11952611

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.