ArticlePsychiatry and clinical neurosciences2025
Validation of the neuropathological criteria of the fourth Consortium on dementia with Lewy Bodies in autopsy cases from psychiatric hospitals.
Article in Psychiatry and clinical neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Progression to Dementia in Very Late-Onset Schizophrenia-Like Psychosis Stratified by Alzheimer's Disease and Lewy Body Disease Biomarkers: A Retrospective Cohort Study.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- Late-life decompensation in longstanding obsessive compulsive disorder: a psychiatric prodrome of dementia with Lewy bodies? A case report.Oxford medical case reports · 2026Article
- Systematized delusions in a patient with covert hepatic encephalopathy: A clinicopathological insight into prodromal dementia with Lewy bodies.PCN reports : psychiatry and clinical neurosciences · 2025Article
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12 authors.
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Abstract
aimThe pathological criteria from the fourth Consortium on Dementia With Lewy bodies (DLB) in psychiatric cohorts has not been validated. Also, the pathological differences in prodromal DLB subtypes remain unclear. This study aimed to elucidate the clinicopathological features of patients with DLB in psychiatric hospitals.
methodsOf 165 autopsied cases, patients who developed psychiatric symptoms at 50 years or older were investigated based on the current criteria of DLB. Clinicopathological findings were compared among prodromal DLB subtypes.
resultsSixteen of 30 cases with DLB pathology had no parkinsonism, which represented diverse nigral neurodegeneration. Regarding the scheme to estimate the likelihood of DLB syndrome, the prevalence of core clinical features excluding rapid eye movement sleep behavior disorder and probable DLB diagnosis were significantly higher in the high-likelihood group than in the low-likelihood group. Regarding the prodromal DLB subtypes, mild cognitive impairment (MCI) onset was identified in 60%, psychiatric onset in 20%, delirium onset in 10%, and motor onset in 10% of cases, and the proportion of psychiatric onset or delirium onset was significantly higher compared with those without DLB pathology. Coexistence of MCI and psychiatric symptoms was observed in 41.6% of the MCI-onset cases. Patients with psychiatric-onset cases were significantly younger at the onset, with a longer disease duration than those with MCI-onset cases. No differences were observed in other clinicopathological variables among the subtypes.
conclusionThe fourth Consortium pathological criteria for DLB were applicable in a psychiatric cohort. MCI-onset cases in conjunction with core clinical features is the main prodromal DLB subtype, and four cases exhibited isolated psychiatric symptoms for long-term duration.
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