Evidence map›Paper›PMID 40162591›Full record

ReviewPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2025

New insights into the mechanisms of childhood food allergies.

Liam Gubbels, Richard Saffery, Melanie R Neeland

Abstract readReview
In one paragraph

Review in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Gastrointestinal manifestations during oral immunotherapy: A guide for pediatric allergists.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Review
  2. Cassava oral immunotherapy in cassava-latex allergy: A pilot study.The journal of allergy and clinical immunology. Global · 2026
    Article
  3. Review
  4. Review
  5. New insights into the mechanisms of childhood food allergies.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Liam GubbelsMolecular Immunity Group, Infection, Immunity and Global Health Theme, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-8132-9646
Richard SafferyMolecular Immunity Group, Infection, Immunity and Global Health Theme, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Melanie R NeelandMolecular Immunity Group, Infection, Immunity and Global Health Theme, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0001-7301-9982

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IgE-mediated food allergies are common and can be life-threatening, especially for children. With increasingly rapid advances in immunological technologies, including the ability to profile highly complex immune features from small sample volumes, our understanding of the immune mechanisms that underpin the development of food allergies continues to grow. This also extends to the immune mechanisms associated with the outcomes of oral immunotherapy (OIT). This review focuses on studies within the past 5 years related to immune signatures associated with food allergy in childhood, immune responses that determine reaction severities to offending allergens, immune alterations that occur during OIT in children, and immune effects of adjunct therapies including omalizumab, dupilumab, and abrocitinib. We conclude by providing a perspective on current evidence and directions for future research that will enable new prediction and screening tools and facilitate the development of effective curative strategies.

Indexed as

Desensitization, ImmunologicFood HypersensitivityAllergensChildHumansImmunoglobulin EAllergensImmunoglobulin Echildhoodfood allergiesimmune mechanismsimmunotherapy

Identifiers

PMID40162591
PMCPMC11956126

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.