ArticlePloS one2025
Microbiome and metabolomic changes in rabbits induced by Folium sennae.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Multidimensional impact analysis of interactive video health intervention on quality of life and clinical rehabilitation indicators in patients with early postoperative bowel obstruction: a randomized controlled trial.International journal of colorectal disease · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diarrhea is a serious health concern in livestock, affecting productivity and animal welfare. However, it remains a significant threat. Various practical therapies are being explored, such as prebiotics, probiotics, and organic acids, as well as chemical treatments including antibiotics, to combat this disorder. This study aims to explore the microbiome and metabolomic changes in rabbits with diarrhea. In the present study, diarrhea was induced in rabbits via oral gavage of Folium Sennae (FSAE), to assess body weights, diarrhea index, serum biochemical indicators, histopathology, microbiota, and metabolomics changes. Our study provides new insights into the mechanism of FSAE-induced diarrhea in rabbits and offers a novel mechanism for the interaction between gut microbiota, metabolomics, and gastrointestinal (GIT) dysfunction. Our results revealed that rabbits receiving FSAE showed a markedly higher diarrhea index and reduced body weight. Notably, levels of somatostatin, substance P, cholecystokinin, 5-hydroxytryptamine, vasoactive intestinal peptide, and acetylcholinesterase were significantly increased compared to control (P < 0.01). However, the levels of gastrin, motilin, enkephalin, and β-Endorphins were significantly decreased (P < 0.01). Microbial analysis revealed a significant reduction in microbial diversity (Shannon, Simpson, ACE, and chao1) and a decrease in Firmicutes, Campilobacterota, and Proteobacteria populations in FSAE-exposed rabbits. Additionally, 13 key metabolites associated with taurine and hypotaurine metabolism, alanine, aspartate and glutamate metabolism, starch and sucrose metabolism, histidine metabolism, and citrate cycle were identified in the colonic tissues. The present study concludes that FSAE-induced diarrhea in rabbits is associated with significant histopathological alterations in the colon, dysregulation of serum biochemical markers, and dysbiosis in metabolomics and gut microbiota. Our findings offer a novel model for investigating GIT dysfunction and its potential treatments.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.