Evidence map›Paper›PMID 40164355›Full record

ArticleInternational journal of radiation oncology, biology, physics2025

NRG Oncology Assessment of Artificial Intelligence for Automatic Treatment Planning in Radiation Therapy Clinical Trials: Present and Future.

Xun Jia, Yi Rong, Qingrong Wu, Carlos E Cardenas, Laurence E Court, William T Hrinivich, Hyejoo Kang, Nataliya Kovalchuk, Thomas J Whitaker, Ying Xiao and 2 more

Abstract read
In one paragraph

Article in International journal of radiation oncology, biology, physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xun JiaDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: xunjia@Jhu.edu.
Yi RongDepartment of Radiation Oncology, Mayo Clinic Arizona, Phoenix, Arizona.
Qingrong WuDepartment of Radiation Oncology, Duke University, Durham, North Carolina.
Carlos E CardenasDepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama.
Laurence E CourtDepartment of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas.
William T HrinivichDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Hyejoo KangDepartment of Radiation Oncology, Loyola University Chicago, Chicago, Illinois.
Nataliya KovalchukDepartment of Radiation Oncology, Stanford University, Stanford, California.
Thomas J WhitakerDepartment of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas.
Ying XiaoDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Pengpeng ZhangDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Quan ChenDepartment of Radiation Oncology, Mayo Clinic Arizona, Phoenix, Arizona.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8M
IROC: Enhancing local enrolling site radiological data capture capabilities for NCTN trialsU24CA180803 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI Thomas J. FitzGerald, MICHAEL V KNOPP · 2014 to 2026
$116.2M
DEEP SOUTH TRANSLATIONAL RESEARCH MENTORED CAREER DEVELOPMENT PROGRAMKL2TR003097 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2019 to 2023
$5.2M
CTSA K12 Program at the University of Alabama at BirminghamK12TR004769 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Renee A. Heffron, Lucio Miele · 2024 to 2026
$4.8M
NCATS NIH HHS K12 TR004769NCATS NIH HHS KL2 TR003097NCI NIH HHS L30 CA242657NCI NIH HHS P30 CA008748NCI NIH HHS U10 CA180868NCI NIH HHS U24 CA180803
6 · The paper itself

Abstract

purposeRecent advances in artificial intelligence (AI) have showcased the potential of automatic treatment planning for clinical trials involving radiation therapy. This paper offers an overview of the current landscape of AI-based treatment planning, emphasizing its ability to improve plan quality and streamline the planning process. METHODS AND MATERIALS: Acknowledging the increasing clinical utilization and promise of these technologies, the NRG Oncology Medical Physcis Subcommittee established a working group to assess the status of AI-based automatic treatment planning for clinical trials, along with its challenges and future directions.

resultsWe describe its critical roles within radiation therapy clinical trials and discuss the challenges of integrating AI into such settings. We further outline short-term actions for enhancing AI-based automatic treatment planning for radiation therapy clinical trials and explore future directions for the field, such as the development of personalized algorithms, the integration of AI into routine clinical practice, and the need for support in this direction.

conclusionsThis assessment provides insights into the present state and prospects of AI in radiation therapy clinical trials to facilitate enhanced treatment planning and patient care.

Indexed as

Artificial IntelligenceClinical Trials as TopicNeoplasmsRadiation OncologyRadiotherapy Planning, Computer-AssistedAlgorithmsHumans

Identifiers

PMID40164355
PMCPMC12228557

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.