ArticleNature communications2025
Optogenetic activation of mechanical nociceptions to enhance implant osseointegration.
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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
–field-weighted citation impact
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Who cites it
13 citing papers in PubMed.
- A novel multifunctional split-type porous biomimetic absorbable mPLA-HA lamina for spinal posterior column reconstruction following laminectomy.Bioactive materials · 2026Article
- Artificial intelligence virtual bone organoids (AIVBOs).Journal of orthopaedic translation · 2026Review
- Dynamic modulation of immune-neural axis via controlled magnesium-releasing nanocapsules accelerates cranial bone regeneration.Journal of nanobiotechnology · 2026Article
- Sustained-release CGRP microspheres accelerate diabetic wound healing by synergistically promoting neurovascular regeneration through modulation of macrophage and endothelial cell functions.Materials today. Bio · 2026Article
- Rational Design of Mechanically Optimized Hydrogels for Bone Tissue Engineering: A Review.Gels (Basel, Switzerland) · 2026Review
- Mechanism-Guided Nanoengineered Therapeutic Peptides for Bone Healing.International journal of nanomedicine · 2026Review
- TRPV1-linked neuropeptide axes in periodontitis and peri-implantitis.Frontiers in endocrinology · 2026Review
- A mechanobiological hypothesis on bone cement-induced progression of bone metastases.Frontiers in bioengineering and biotechnology · 2026Article
- Magnesium-containing implants enhance bone healing: A mechanobiological perspective.Mechanobiology in medicine · 2025Review
- 3D printing combined with thermally induced phase separation for engineering hierarchical osteogenic PLA scaffolds.Materials today. Bio · 2025Article
- Comparative analysis of nerve fibers, PIEZO family and bone structural parameters difference surrounding dental implants.BMC oral health · 2025Article
- Review
- Frontiers in mechanobiology and mechanomedicine.Med-X · 2025Article
Corrections and comments
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Authors and funding
23 authors.
Qijin Wang *Department of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.ORCID http://orcid.org/0000-0001-6978-653X
Yang Chen *Department of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Haiqi Ding *Department of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Yuanqing Cai *Department of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Xuhui YuanDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Jianhua LvDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Jiagu HuangDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Jiexin HuangDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Chaofan ZhangDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Zihao HongDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Hongyan LiDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Ying HuangDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Jiamin LinDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Lin YuanDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Lan LinDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Shaolin YuDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Canhong ZhangDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Jianhua LinDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Wenbo LiDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Cheng ChangInstitute of New Materials, Guangdong Academy of Sciences, Guangdong-Hong Kong Joint Laboratory of Modern Surface Engineering Technology, Guangdong Provincial Key Laboratory of Modern Surface Engineering Technology, Guangzhou, Guangdong, PR China.
Bin YangDepartment of Laboratory Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China. yangbin2864@163.com.ORCID http://orcid.org/0000-0002-5139-5888
Wenming ZhangDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China. zhangwm0591@fjmu.edu.cn.ORCID http://orcid.org/0000-0003-1567-7279
Xinyu FangDepartment of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China. fangxinyu0417@fjmu.edu.cn.ORCID http://orcid.org/0000-0001-6337-8009
Funding
National Natural Science Foundation of China (National Science Foundation of China) 82272510National Natural Science Foundation of China (National Science Foundation of China) 82371375
Abstract
Orthopedic implants with high elastic modulus often suffer from poor osseointegration due to stress shielding, a phenomenon that suppresses the expression of intracellular mechanotransduction molecules (IMM) such as focal adhesion kinase (FAK). We find that reduced FAK expression under stress shielding is also mediated by decreased calcitonin gene-related peptide (CGRP) released from Piezo2
Indexed as
OptogeneticsOsseointegrationAnimalsCalcitonin Gene-Related PeptideCyclic AMP-Dependent Protein KinasesFocal Adhesion Kinase 1Ganglia, SpinalIon ChannelsMaleMechanotransduction, CellularMesenchymal Stem CellsMiceMice, Inbred C57BLNeuronsOsteogenesisProstheses and ImplantsCalcitonin Gene-Related PeptideCyclic AMP-Dependent Protein KinasesFocal Adhesion Kinase 1Ion ChannelsPiezo2 protein, mouse
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.