Evidence map›Paper›PMID 40164771›Full record

ArticleNature aging2025

Transcriptional profiles of mouse oligodendrocyte precursor cells across the lifespan.

Dongeun Heo, Anya A Kim, Björn Neumann, Valerie N Doze, Yu Kang T Xu, Yevgeniya A Mironova, Jared Slosberg, Loyal A Goff, Robin J M Franklin, Dwight E Bergles

Abstract read
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In one paragraph

Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  15. Glial Cells and Aging: From the CNS to the Cerebellum.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Dongeun HeoThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-4913-2253
Anya A KimThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.
Björn NeumannWellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Valerie N DozeThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.
Yu Kang T XuThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.
Yevgeniya A MironovaThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.
Jared SlosbergDepartment of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-1803-2815
Loyal A GoffThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.
Robin J M FranklinWellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Dwight E BerglesThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA. dbergles@jhmi.edu.ORCID http://orcid.org/0000-0002-7133-7378

Funding

National Multiple Sclerosis Society (National MS Society) FG-1708-28962
6 · The paper itself

Abstract

Oligodendrocyte progenitor cells (OPCs) are highly dynamic, widely distributed glial cells of the central nervous system responsible for generating myelinating oligodendrocytes throughout life. However, the rates of OPC proliferation and differentiation decline dramatically with aging, which may impair homeostasis, remyelination and adaptive myelination during learning. To determine how aging influences OPCs, we generated a transgenic mouse line (Matn4-mEGFP) and performed single-cell RNA sequencing, providing enhanced resolution of transcriptional changes during key transitions from quiescence to proliferation and differentiation across the lifespan. We found that aging induces distinct transcriptomic changes in OPCs in different states, including enhanced activation of HIF-1α and WNT pathways. Pharmacological inhibition of these pathways in aged OPCs was sufficient to increase their ability to differentiate in vitro. Ultimately, Matn4-mEGFP mouse line and the sequencing dataset of cortical OPCs across ages will help to define the molecular changes guiding OPC behavior in various physiological and pathological contexts.

Indexed as

AgingLongevityOligodendrocyte Precursor CellsOligodendrogliaTranscriptomeAnimalsCell DifferentiationCell ProliferationHypoxia-Inducible Factor 1, alpha SubunitMiceMice, TransgenicSingle-Cell AnalysisWnt Signaling PathwayHypoxia-Inducible Factor 1, alpha Subunit

Identifiers

PMID40164771

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.