Trial reportQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2025
Effects of WeChat-based EPIC training on health-related quality of life, attribution and life attitude in women newly diagnosed with breast cancer: a clinical randomized controlled trial.
Trial report in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeWhen confronted with healthy functional impairments, the attribution of disease-induced distress plays a key role in the prognosis of health outcomes. This study examined the effects of an attribution-related intervention, namely WeChat-based EPIC (enter, practice, intensify, consolidate) training, on health-related quality of life (HRQoL), attribution, and life attitude in women newly diagnosed with breast cancer.
methodsEligible patients were recruited using convenience sampling and randomly assigned to the intervention or control group via stratified block randomization. The former received WeChat-based EPIC training plus routine nursing care for 6 months. The latter received only routine nursing care. HRQoL (primary indicator), attribution and life attitude (secondary indicators) were measured using the Functional Assessment of Cancer Therapy-Breast version 4.0 (FACT-Bv4.0), Attributional Style Questionnaire (ASQ) and Life Attitude Self-rating Questionnaire for Breast Cancer (LASQ-BC), respectively. A linear mixed model was used to examine the score fluctuations at the 1-, 3-, and 6-month intervals relative to the baseline.
resultsAfter 6 months, the intervention group (n = 84) showed statistically significant higher total scores in the FACT-Bv4.0 [mean difference: - 15.01; 95% confidence interval: - 17.96, - 12.07; p < 0.001], ASQ [- 4.16 (- 4.45, - 3.86); p < 0.001], and LASQ-BC [- 6.77 (- 8.27, - 5.27); p < 0.001] than that of the control group (n = 82). The total scores of the three indicators also showed significant group, time, and group-by-time interaction effects (p < 0.001).
conclusionThe WeChat-based EPIC training was an effective intervention for improving HRQoL and psychological health in women newly diagnosed with breast cancer.
trial registrationChinese Clinical Trial Registry www.chictr.org.cn , prospectively registered on 11 April 2020, ChiCTR2000031827.
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