Evidence map›Paper›PMID 40165121›Full record

ArticleBMC infectious diseases2025

Evaluation of QuantiFERON TB gold plus among TB household contacts in high incidence settings.

Sophie Nalukwago, Bonnie Thiel, Keith Chervenak, AnnaRitah Namuganga, LaShaunda L Malone, Mary Nsereko, W Henry Boom, Harriet Mayanja-Kizza

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sophie NalukwagoJoint Clinical Research Centre, Kampala, Uganda. snalukwago@jcrc.org.ug.
Bonnie ThielTuberculosis Research Unit (TBRU), Case Western Reserve University, Cleveland, OH, USA.
Keith ChervenakTuberculosis Research Unit (TBRU), Case Western Reserve University, Cleveland, OH, USA.
AnnaRitah NamugangaUganda-Case Western Reserve University Research Collaboration, Kampala, Uganda.
LaShaunda L MaloneTuberculosis Research Unit (TBRU), Case Western Reserve University, Cleveland, OH, USA.
Mary NserekoUganda-Case Western Reserve University Research Collaboration, Kampala, Uganda.
W Henry BoomTuberculosis Research Unit (TBRU), Case Western Reserve University, Cleveland, OH, USA.
Harriet Mayanja-KizzaUganda-Case Western Reserve University Research Collaboration, Kampala, Uganda.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccurately identifying and categorizing individuals who are latently infected is critical for developing prevention strategies against tuberculosis (TB) disease. The QuantiFERON-TB Gold Plus (QFT-Plus), a set of two antigen tubes, was used to assess TB household contacts, aiming to induce CD4 + and CD8 + T cell responses.

methodsWe examined fifty-six TB household contacts for TB infection using the QFT-Plus and QFT-Gold In-Tube (QFT-GIT) tests. In addition, we evaluated 616 samples from the parent study to determine whether there was any association between the QFT-Plus CD8 + T cell responses and variables that were clinically significant. This was done by analyzing the difference in interferon-gamma (IFNγ) levels between TB2 and TB1 tubes. We utilised a cut-off of 0.6 IU/mL.

resultsTo assess agreement between tests, a Cohen's kappa of 0.71 was observed across 56 TB contacts. Eight participants reported discordance: four reported positive QFT-Plus and negative QFT-GIT, and four reported negative QFT-Plus and positive QFT-GIT. The QFT-Plus CD8 + T cell responses did not show any significant correlation with the age, sex, history of BCG vaccination, HIV infection, TB risk score and baseline blood draw among adult TB household contacts.

conclusionThe QFT-Plus and QFT-GIT tests significantly agree with one another. No clinically significant variable was observed to be associated with CD8 + T cell responses in QFT-Plus.

Indexed as

Interferon-gamma Release TestsLatent TuberculosisTuberculosisAdolescentAdultAgedCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChildContact TracingFamily CharacteristicsFemaleHumansIncidenceInterferon-gammaMaleInterferon-gammaIGRAQFT-GITQFT-plusTuberculosis

Identifiers

PMID40165121
PMCPMC11959818

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.