Evidence map›Paper›PMID 40165123›Full record

ArticleBMC pregnancy and childbirth2025

Utility of maternal A1c measurement in the second trimester for the diagnosis of gestational diabetes mellitus.

Neval Cayonu Kahraman, Gonca Karatas Baran, Ozge Yucel Celik, Sitara Aslanova, Irem Ozge Uzunoglu Mehrasa, Dıcle Mutel Gurer, Ali Turhan Çaglar, Yaprak Engin Üstün

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Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Neval Cayonu KahramanPerinatology Department, University of Health Sciences Etlik Zübeyde Hanım Women'S Health Care, Training and Research Hospital, Ankara, Turkey. nevalcayonu@gmail.com.ORCID http://orcid.org/0000-0001-8832-0081
Gonca Karatas BaranPerinatology Department, University of Health Sciences Etlik Zübeyde Hanım Women'S Health Care, Training and Research Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0002-7996-6144
Ozge Yucel CelikPerinatology Department, University of Health Sciences Etlik Zübeyde Hanım Women'S Health Care, Training and Research Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0002-7746-1943
Sitara AslanovaPerinatology Department, University of Health Sciences Etlik Zübeyde Hanım Women'S Health Care, Training and Research Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0003-3388-8221
Irem Ozge Uzunoglu MehrasaPerinatology Department, University of Health Sciences Etlik Zübeyde Hanım Women'S Health Care, Training and Research Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0003-0500-2497
Dıcle Mutel GurerPerinatology Department, University of Health Sciences Etlik Zübeyde Hanım Women'S Health Care, Training and Research Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0001-6929-4922
Ali Turhan ÇaglarPerinatology Department, University of Health Sciences Etlik City Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0002-7022-3029
Yaprak Engin ÜstünPerinatology Department, University of Health Sciences Etlik Zübeyde Hanım Women'S Health Care, Training and Research Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0002-1011-3848

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the effectiveness of maternal hemoglobin A1c (HbA1c) in the diagnosis of gestational diabetes mellitus (GDM) in the second trimester.

methodsA total of 3000 pregnant women between 24 and 28 weeks of gestation were included in the study. Screening for gestational diabetes was performed using maternal HbA1c in 1200 pregnant women who either refused or could not tolerate the OGTT. The HbA1c value for the diagnosis of GDM was set at ≥ 5.7% in accordance with a meta-analysis by Paula B. Renz et al. A total of 154 pregnant women with HbA1c ≥ 5.7% were diagnosed with gestational diabetes, and their data were recorded prospectively. These data were compared with obstetric outcomes in 250 pregnant women diagnosed with diabetes by performing a 100-g OGTT after a 50-g glucose challenge test (GCT).

resultsThere were no significant differences between two groups in terms of maternal age, gestational age at diagnosis, gravidity, and parity. Body mass index (BMI) was found to be significantly higher in pregnant women with HbA1c levels ≥ 5.7% (p < 0.001). Polyhydramnios was more common in the HbA1c ≥ 5.7% group and oligohydramnios was more common in the OGTT group (p < 0.001). Neonatal hypoglycemia was found to be significantly higher in the OGTT group (p < 0.05). The median HbA1c value were different in each group (OGTT group 5.6%, HbA1c group 5.8%; p < 0.001).

conclusionHbA1c testing has lower accuracy rates than OGTT in diagnosing GDM because it may miss diagnosis in some groups.

Indexed as

Diabetes, GestationalGlycated HemoglobinPregnancy Trimester, SecondAdultFemaleGlucose Tolerance TestHumansInfant, NewbornPregnancyProspective StudiesGlycated Hemoglobinhemoglobin A1c protein, humanGestational diabetes mellitusHbA1cOral glucose tolerance testPoor obstetric outcome

Identifiers

PMID40165123
PMCPMC11956492

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.