ArticleBMC psychiatry2025
Inflammatory burden index is correlated with increased depression: a population-based study.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Inflammation burden index as a complementary marker for the assessment of hepatic steatosis and fibrosis: evidence from NHANES 2017-2018.Abdominal radiology (New York) · 2026Article
- Association between ALBI score and stroke risk and all-cause mortality: 2011 to 2018 NHANES.Medicine · 2025Article
- Xiaoyao San against depression via glia-mediated neuroinflammation using network pharmacology and experimental validation.Scientific reports · 2025Article
- Neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) mediates the relationship between abdominal fat index and depression in a cross-sectional study.BMC psychiatry · 2025Article
- Association between dietary niacin intake and suicidal ideation: mediating role of C-reactive protein.BMC psychiatry · 2025Article
- Inflammation and Cognition in Bipolar Disorder: Diverging Paths of Interleukin-6 and Outcomes.International journal of molecular sciences · 2025Article
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Abstract
backgroundDepression is intricately correlated with systemic inflammatory responses. The Inflammatory Burden Index (IBI) has recently been introduced as a comprehensive metric for evaluating systemic inflammation. This study aims to explore the correlation between IBI and depression in the general population.
methodsThis cross-sectional study was designed to analyze the data from National Health and Nutrition Examination Survey (NHANES) during the period from 1999 to 2018. IBI was formulated as C-reactive protein×neutrophils/lymphocytes. The correlation between the prevalence of depression and IBI was explored through multivariate logistic regression analyses, as well as subgroup, interaction, restricted cubic spline (RCS) and sensitivity analyses.
resultsA total of 14,557 subjects were included in this study, of whom, 1231 (8.5%) had depression. According to multivariate logistic regression and RCS analyses, a significantly linearly positive correlation was observed between IBI and depression [odds ratio (OR) = 1.03, 95% confidence intervals (CI): 1.01, 1.05, P = 0.007]. Subjects in the third tertile of IBI exhibited a significantly higher prevalence of depression, with 40.0% affected, compared to those in the first tertile (P < 0.001). This correlation was consistently observed across all subgroups through stratified analysis (all interaction P > 0.05). After sensitivity analyses excluding participants with upper and lower 2.5% of IBI, the correlation between IBI and depression remained stable (OR = 1.08; 95%CI, 1.01, 1.15, P < 0.001).
conclusionThese findings in this study indicate a positive correlation between IBI and depression in American adults. Further large-scale prospective studies are still needed to analyze the role of IBI in depression.
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