ArticleBMC veterinary research2025
The protective role of melatonin and agomelatine against oxidative stress following laparoscopic ovariectomy in dogs.
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Effects of Topical Administration of Bupivacaine HCl to the Ovarian Pedicle on Postoperative Pain, Antioxidant Enzyme Activity and Inflammatory Cytokines in Dogs Undergoing Laparoscopic Ovariectomy.Veterinary medicine and science · 2026Article
- Comparative Evaluation of Oxidative Stress, Cortisol, Inflammatory Response, and Systemic COAntioxidants (Basel, Switzerland) · 2026Article
- Effects of Laparoscopic and Open Ovariectomy on Cortisol and Oxidative Stress in Dogs Under the Same Anesthesia Protocol.Veterinary sciences · 2026Article
- Assessment of Pain, Vital Parameters and Oxidative Stress Markers in Dogs After Celiotomy and Three-Port Laparoscopic Ovariectomy.Veterinary medicine and science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present study was carried out to compare biomarkers of oxidative stress and antioxidant activity of agomelatine and melatonin in bitches undergoing laparoscopic ovariectomy. Twenty-four healthy female dogs were randomly divided into four groups: Control (C), laparoscopic ovariectomy (LO), agomelatine + laparoscopic ovariectomy (ALO), and melatonin + laparoscopic ovariectomy (MLO) consisting of 6 animals each. Melatonin and agomelatine were administered to the MLO group (0.3 mg/kg/day, p.o) and the ALO group (0.3 mg/kg/day, p.o) consequently one day before LO to 7 days post-intervention. Blood sampling was performed on days - 1, 0 (immediately after surgery), 3, and 8 of the study. Total oxidant status (TOS), total antioxidant capacity (TAC), and malondialdehyde (MDA) in sera and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in hemolyzed red blood cells (RBCs) were measured.
resultsAmong all indices analyzed over time, only the MDA index in the ALO group showed a significant difference, being significantly lower on day 3 post-surgery compared to days - 1 and 0 (p = 0.023). Significant differences were observed between groups in terms of TOS, TAC, GPx, and SOD levels. The LO group exhibited a significant increase in the TOS index on day 3 compared to all other groups (p = 0.008). The TAC index experienced the most significant increase in the MLO group on day 0 compared to other groups (p = 0.005), and this trend continued significantly until day 3, only in comparison to the LO and C groups (p = 0.024). Agomelatine significantly increased SOD levels in the ALO group on postoperative day 3 compared to groups C and LO (p = 0.009). GPx levels were significantly elevated in ALO and MLO groups on day 8 compared to groups C and LO (p = 0.003).
conclusionThe results of this study demonstrate that melatonin, by increasing total antioxidant capacity, and agomelatine, through enzymatic antioxidant pathways, contributed to the reduction of free radical levels in dogs. The present study revealed that administering agomelatine (0.3 mg/kg/day, p.o) could decrease MDA levels significantly after laparoscopic ovariectomy up to day 3.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.