ArticlebioRxiv : the preprint server for biology2025
FM-dye inhibition of Piezo2 relieves acute inflammatory and osteoarthritis knee pain in mice of both sexes.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Musculoskeletal pain is a significant burden affecting billions of people with little progress in the development of pharmaceutical pain relief options. The mechanically-activated ion channel Piezo2 has been shown to play a role in mechanical sensitization; however there has been little progress in examining therapeutics that target this molecule. The goal of this study was to assess the effect of two FM-dyes, FM1-43 or FM4-64, in reducing acute inflammatory and osteoarthritis knee joint pain in mice of both sexes. In our acute model of Complete Freund's adjuvant (CFA)-induced joint pain, mice intra-articularly injected with FM1-43 exhibited an attenuation of knee hyperalgesia 90 minutes following injection.
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