Evidence mapPaperPMID 40166299Full record

ArticlebioRxiv : the preprint server for biology2025

Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression.

Verena van der Heide, Sara McArdle, Michael S Nelson, Karen Cerosaletti, Sacha Gnjatic, Zbigniew Mikulski, Amanda L Posgai, Irina Kusmartseva, Mark Atkinson, Dirk Homann

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Verena van der HeideMarc and Jennifer Lipschultz Precision Immunology Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.ORCID 0000-0002-3602-4405
Sara McArdleMicroscopy and Histology Core Facility, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA.ORCID 0000-0003-3795-3772
Michael S NelsonDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.
Karen CerosalettiCenter for Translational Immunology, Benaroya Research Institute, Seattle, WA 98101, USA.
Sacha GnjaticMarc and Jennifer Lipschultz Precision Immunology Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
Zbigniew MikulskiMicroscopy and Histology Core Facility, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA.ORCID 0000-0002-1918-9216
Amanda L PosgaiDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida Diabetes Institute, College of Medicine, Gainesville, FL 32610, USA.ORCID 0000-0002-9491-0958
Irina KusmartsevaDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida Diabetes Institute, College of Medicine, Gainesville, FL 32610, USA.ORCID 0000-0003-2614-0813
Mark AtkinsonDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida Diabetes Institute, College of Medicine, Gainesville, FL 32610, USA.ORCID 0000-0001-8489-4782
Dirk HomannMarc and Jennifer Lipschultz Precision Immunology Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.ORCID 0000-0002-7622-5754

Funding

Targeting the Chemokine System to Sensitize Tumors to ImmunotherapyP01CA234212 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Robert Page Edwards · 2023 to 2023
$5.8M
The Tisch Cancer Institute - Cancer Center Support GrantP30CA196521 · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2025 to 2025
$3.1M
NYR-Diabetes Research Center (NYR-DRC)P30DK020541 · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2025 to 2025
$2.4M
High-Dimensional Immune Monitoring of NCI-Supported Immunotherapy TrialsU24CA224319 · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2025 to 2025
$2.0M
Integrated Functional Histopathology of the Diabetic Human PancreasR01AI134971 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI DIRK HOMANN, Matthias G. Von Herrath · 2021 to 2022
$1.4M
NCI NIH HHS P01 CA234212NCI NIH HHS P30 CA196521NCI NIH HHS U24 CA224319NIAID NIH HHS R01 AI134971NIDDK NIH HHS P30 DK020541NIDDK NIH HHS R01 DK130425NIDDK NIH HHS U01 DK124165NIEHS NIH HHS R21 ES027916
6 · The paper itself

Abstract

Type 1 diabetes (T1D) is a progressive autoimmune condition that culminates in the loss of insulin-producing beta cells. Pancreatic histopathology provides essential insights into disease initiation and progression yet an integrated perspective of

Indexed as

beta cellsdigital pathologyendocrine pancreashistopathologyimmune cellsislet of Langerhansmultiplex imagingQuPathsemi-automated image analysistype 1 diabetes (T1D)whole slide imaging

Identifiers

PMID40166299
PMCPMC11956956

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.