Evidence map›Paper›PMID 40166543›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Plant based enteral nutrition outperforms artificial nutrition in mitigating consequences of antibiotic-induced dysbiosis in mice and humans.

Mona Chatrizeh, Jianmin Tian, Matthew Rogers, Firuz Feturi, Guojun Wu, Brian Firek, Roman Nikonov, Lauren Cass, Alexandra Sheppeck, Rafael G Ramos-Jiménez and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Mona ChatrizehDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jianmin TianDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Matthew RogersDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Firuz FeturiDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Guojun WuDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Brian FirekDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Roman NikonovDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Lauren CassDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Alexandra SheppeckDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Rafael G Ramos-JiménezDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Lavnish OhjaDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Ali CarollDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Mathew HenkelDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Justin AzarDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Rajesh K AnejaDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Brian CampfieldDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Dennis SimonDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Michael J MorowitzDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Funding

TRAINING PROGRAM FOR MD/PHD STUDENTST32GM008208 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STEINMAN, RICHARD A · 1987 to 2021
$15.4M
Microbiome targeted nutrition to improve immune function during critical illnessF30HL170777 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mona Chatrizeh · 2023 to 2026
$223k
NHLBI NIH HHS F30 HL170777NIGMS NIH HHS T32 GM008208
6 · The paper itself

Abstract

Malnutrition, gut inflammation, and antibiotic induced dysbiosis (AID) are omnipresent risk factors for poor clinical outcomes among critically ill patients. We previously showed that commercially available plant-based enteral nutrition (PBEN) preserves a commensal microbiome when compared to commonly used forms of commercially available artificial enteral nutrition (AEN). This study reveals that PBEN is superior to artificial enteral nutrition (AEN) in recovering from antibiotic-induced dysbiosis (AID) in mice and humans. PBEN effectively mitigates anemia, leukopenia, restores naïve lymphocyte populations, and reduces bone marrow myeloid cell expansion. Animals randomized to PBEN also fared better in response to infectious challenges after antibiotics. A pilot clinical study validated these findings, showing increased gut commensals, reduced pathogens, and improved leukocyte balance in critically ill patients receiving PBEN compared to AEN. These results suggest PBEN offers a practical dietary approach to mitigate antibiotic-associated complications and improve clinical outcomes among hospitalized patients requiring supplemental nutrition.

Indexed as

Antibiotic Induced DysbiosisBacterial TranslocationDysbiosisGastrointestinal infectionPlant-Based NutritionVancomycin-Resistant Enterococcus

Identifiers

PMID40166543
PMCPMC11957089

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.