Evidence map›Paper›PMID 40166588›Full record

ArticleResearch and practice in thrombosis and haemostasis2025

The Functional Characterization of Venous Thromboembolic Disease (FUVID) study: rationale, design, and methods of a prospective, observational, multicenter study to evaluate mechanisms of exercise intolerance and dyspnea following pediatric pulmonary embolism.

Ayesha Zia, Michael D Nelson, Jimin Ren, Song Zhang, Robert F Mattrey, Brian L Han, Tarique Hussain, Joshua S Greer, Manal Al-Qahtani, Kendra Malone and 35 more

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In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Ayesha ZiaDivision of Hematology/Oncology, Departments of Pediatrics, Children's Health System of Texas, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Michael D NelsonDepartment of Kinesiology, University of Texas at Arlington, Arlington, Texas, USA.
Jimin RenDivision of Hematology/Oncology, Departments of Pediatrics, Children's Health System of Texas, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Song ZhangDivision of Hematology/Oncology, Departments of Pediatrics, Children's Health System of Texas, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Robert F MattreyDivision of Hematology/Oncology, Departments of Pediatrics, Children's Health System of Texas, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Brian L HanDivision of Hematology/Oncology, Departments of Pediatrics, Children's Health System of Texas, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Tarique HussainDivision of Hematology/Oncology, Departments of Pediatrics, Children's Health System of Texas, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Joshua S GreerDivision of Hematology/Oncology, Departments of Pediatrics, Children's Health System of Texas, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Manal Al-QahtaniDivision of Hematology/Oncology, Departments of Pediatrics, Children's Health System of Texas, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Kendra MaloneDivision of Hematology/Oncology, Children's Health System of Texas, Dallas, Texas, USA.
Sonja E StutzmanDivision of Hematology/Oncology, Departments of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Deseray V SidaDivision of Hematology/Oncology, Departments of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Sharon PrimeauxDivision of Hematology/Oncology, Departments of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Marcela D TorresDivision of Hematology/Oncology, Cook Children's Medical Center, Forth worth, Texas, USA.
Clay T CohenDivision of Hematology/Oncology, Baylor College of Medicine, Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA.
Shelley CraryDivision of Hematology/Oncology, Departments of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, Texas, USA.
Jonathan BernsteinDivision of Hematology/Oncology, Penn State Hershey Children's Hospital, Hershey, Pennsylvania, USA.
Hilary B WhitworthDivision of Hematology/Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Riten KumarDivision of Hematology/Oncology, Departments of Pediatrics, Harvard Medical School, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.
Kisha A BegDivision of Hematology/Oncology, Departments of Pediatrics, Oklahoma University Health, Oklahoma Children's Hospital, Oklahoma City, Oklahoma, USA.
Osman KhanDivision of Hematology/Oncology, Departments of Pediatrics, Oklahoma University Health, Oklahoma Children's Hospital, Oklahoma City, Oklahoma, USA.
Madhvi RajpurkarDivision of Hematology/Oncology, Departments of Pediatrics, Central Michigan University, Detroit, Michigan, USA.
Kerry HegeDivision of Hematology/Oncology, Departments of Pediatrics, Riley Children's Health, Indianapolis, Indiana, USA.
Beverly A SchaeferDivision of Hematology/Oncology, Departments of Pediatrics, Roswell Park and Oishei Children's Hospital, Buffalo, New York, USA.
Gary M WoodsDivision of Hematology/Oncology, Departments of Pediatrics, Emory University School of Medicine, Aflac Cancer and Blood Disorder Center, Atlanta, Georgia, USA.
Lauren E AmosDivision of Hematology/Oncology, Departments of Pediatrics, Children's Mercy Kansas City, Missouri, USA.
Marisol BetenskyJohns Hopkins School of Medicine, Johns Hopkins All Children's Hospital, Cancer and Blood Disorders Institute, St. Petersburg, Florida, USA.
Rukhmi V BhatNorthwestern University Feinberg School of Medicine, Anne & Robert H. Lurie Children's Hospital of Chicago, Center for Cancer and Blood Disorders, Chicago, Illinois, USA.
Sarah O' BrienDivision of Hematology/Oncology, Departments of Pediatrics, Nation Wide Children's Hospital, Columbus, Ohio, USA.
Julie JaffrayDivision of Hematology/Oncology, Departments of Pediatrics, University of California at San Deigo, Rady Children's Hospital, San Diego, California, USA.
Rohit JesudasDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Martha M PachecoDepartments of Pediatrics, St. Lukes Children's Cancer Institute, Boise, Idaho, USA.
Cristina TarangoDivision of Hematology, Departments of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Angela C WeyandDivision of Hematology/Oncology, Departments of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Hope P WilsonDivision of Hematology/Oncology, Departments of Pediatrics, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Jessica GarciaDivision of Hematology/Oncology, Departments of Pediatrics, Children's Health System of Texas, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Mary P DangDivision of Hematology/Oncology, Departments of Pediatrics, Children's Health System of Texas, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ruchika SharmaDivision of Hematology/Oncology, Departments of Pediatrics, Children's Health System of Texas, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Neil A GoldenbergJohns Hopkins School of Medicine, Johns Hopkins All Children's Hospital, Johns Hopkins All Children's Institute for Clinical and Translational Research, St. Petersburg, Florida, USA.
Frederikus A KlokDivision of Thrombosis and Hemostasis, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.
Christoph MaleDepartments of Pediatrics, Medical University of Vienna, Vienna, Austria.
Benjamin LevineDivision of Cardiology, Department of Internal Medicine, Institute of Exercise and Environmental Science, Dallas, Texas, USA.
Bryce N BalmainDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Institute of Exercise and Environmental Science, Dallas, Texas, USA.
Tony G BabbDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Institute of Exercise and Environmental Science, Dallas, Texas, USA.
FUVID Investigators

Funding

NHLBI NIH HHS R01 HL153963NHLBI NIH HHS R56 HL153963
6 · The paper itself

Abstract

Background: To date, the focus of investigation in pediatric pulmonary embolism (PE) has been on PE recurrence and anticoagulant-related bleeding. While highly relevant, these outcomes do not fully capture functional limitations and the psychological impact that comprises post-PE syndrome. Objectives: The primary objective of the Functional Characterization of Venous Thromboembolic Disease (FUVID) study was to investigate mechanisms of post-PE syndrome in children. Methods: The ongoing FUVID study will prospectively enroll and systematically follow, over 12 months and with standardized pulmonary, cardiac, and muscle testing, a multicenter prospective cohort of 80 pediatric patients with first-episode PE without comorbidities. FUVID has 2 coprimary outcomes: exercise intolerance and exertional dyspnea. Exercise intolerance will be defined objectively as a percent predicted peak oxygen uptake based on ideal body weight or milliliters per minute per kilogram of lean body mass during cardiopulmonary exercise testing. Dyspnea will be objectively quantified using Borg questionnaires and defined as a mean difference of >1 at the end of the warm-up and submaximal work rates during exercise testing, simulating conditions during daily life that induce dyspnea. Pertinent secondary outcomes include anxiety, depression, and quality of life. Conclusion: The FUVID study will investigate the relationship between symptoms (exercise intolerance and exertional dyspnea) and multiple mechanisms-hemodynamic, ventilatory, or peripheral/muscle-within the same patient at rest, submaximal exercise (simulating activities of daily living), and maximal exercise using objective measures. It will provide new evidence for selecting patients for long-term follow-up, including psychological sequelae, after PE, the modalities this follow-up should include, and the findings interpreted as indicating functional limitations after PE.

Indexed as

childrenpediatricspost–pulmonary embolism syndromepulmonary embolismvenous thromboembolism

Identifiers

PMID40166588
PMCPMC11957776

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.