Trial reportThe Journal of clinical endocrinology and metabolism2025
Melatonin as a Possible Stimulus to Unmask an Oxytocin-Deficient State in Hypopituitarism and Hypothalamic Damage.
Trial report in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05319301 (Identification and Clinical Relevance of an Oxytocin Deficient State Following Melatonin Administration in Patients With Hypopituitarism), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Identification and Clinical Relevance of an Oxytocin Deficient State Following Melatonin Administration in Patients With Hypopituitarism: a Proof-of-concept, Physiopathological Study With a Control Group
Who cites it
6 citing papers in PubMed.
- Melatonin as a Possible Stimulus to Unmask an Oxytocin-Deficient State in Hypopituitarism and Hypothalamic Damage.The Journal of clinical endocrinology and metabolism · 2025Trial
- Low Dose Ketamine Preconditions Astrocyte Mitochondria to Achieve Antidepressant Efficacy via Adenosine, Humanin, and Melatonin Upregulation and Efflux.Alpha psychiatry · 2026Article
- Neurophysin-I dynamics upon different pituitary provocation tests in healthy participants.Endocrine connections · 2026Article
- Arginine Vasopressin Deficiency and Oxytocin Deficiency in the Endocrine Clinic.The Journal of clinical endocrinology and metabolism · 2026Review
- Oxytocin: a neglected hormone in pituitary disease - From function to the diagnosis of a deficiency, resulting clinical relevance, and potential treatment options in endocrinology.Archives of endocrinology and metabolism · 2025Review
- Editorial for Special Issue "Current Advances in Oxytocin Research".Current issues in molecular biology · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
contextIncreasing evidence supports the presence of oxytocin deficiency (OXT-D) in hypopituitarism and hypothalamic damage (HHD). Identifying an applicable and reliable test to diagnose OXT-D is an unmet need. Melatonin (MEL) might be a candidate for such a test as it regulates OXT release in animals.
objectiveThis work aimed to examine the effects of melatonin on OXT release in HHD compared to healthy controls (HCs) and to describe the psychopathology, sexual function, and quality of life (QoL) and their associations with OXT.
methodsThis proof-of-concept study (NCT05319301) included 20 participants with HHD (11 women) and 20 HCs (11 women). Blood samples were collected over 120 minutes to assess plasma OXT. A linear mixed-effects regression model was used to evaluate the change in OXT in response to MEL in HHD compared to HCs.
resultsMEL significantly increased OXT at T90 vs T0 in HCs compared to the HHD group (difference 14.57 pg/mL 26% increase; 95% CI, 1.90-27.23; P = .02). The HHD group had more depression symptoms, alexithymia, impaired sexual function, and worse QoL compared to HCs. The mean percentage change in OXT from T0 to T90 was negatively associated with depressive and alexithymia symptoms in the HHD group and anxiety in both groups.
conclusionThe reduced OXT response after MEL in HHD supports the existence of an impaired OXT response at least in a subset of patients with HHD. The associations between OXT changes and psychopathology suggest its role in mood and QoL. These findings support further investigation into MEL's role as a diagnostic tool to address OXT-D.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.