ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Activation of Glutamatergic Neurons in the Supramammillary Nucleus Promotes the Recovery of Consciousness under Sevoflurane Anesthesia.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Transcriptomic Profiling in Aged Mice Reveals an Association Between Sevoflurane Anesthesia and Neurocognitive Dysfunction.Cellular and molecular neurobiology · 2026Article
- Long-term outcomes and age-dependent recovery trajectories following short-term spinal cord stimulation in patients with disorders of consciousness.Frontiers in neurology · 2026Article
- Nucleus Accumbens Dopamine Levels Fluctuate Across Different States of Consciousness Under Sevoflurane Anesthesia.Brain sciences · 2025Article
- Activation of Glutamatergic Neurons in the Supramammillary Nucleus Promotes the Recovery of Consciousness under Sevoflurane Anesthesia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Volatile anesthetics have been widely applied during surgery, but the potential mechanisms by which they influence loss of consciousness (LOC), anesthesia maintenance, and recovery of consciousness (ROC) from anesthesia remain largely unknown. Recent studies have suggested that anesthesia-induced unconsciousness may be due to specific interactions between neural circuits that regulate sleep and wakefulness. Supramammillary (SuM) glutamatergic neurons are essential for sleep-wakefulness regulation. However, whether SuM glutamatergic neurons are involved in the modulation of consciousness under sevoflurane anesthesia is unclear. Here, it is shown that the activity of SuM glutamatergic neurons decreased prior to sevoflurane-induced LOC and gradually increased following ROC. Selective lesioning of SuM glutamatergic neurons promoted the induction of and delayed emergence from sevoflurane anesthesia and increased sevoflurane sensitivity. In addition, optogenetic stimulation of SuM glutamatergic neurons or the SuM-MS projection promoted behavioral arousal and cortical activation under steady-state sevoflurane anesthesia (SSSA) and reduced the depth of anesthesia and caused cortical arousal under sevoflurane-induced burst-suppression conditions. Collectively, these results provide compelling evidence that SuM glutamatergic neurons contribute to regulating states of consciousness under sevoflurane anesthesia.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.