Evidence map›Paper›PMID 40167305›Full record

ArticlemBio2025

Biochemical mapping reveals a conserved heme transport mechanism via CcmCD in System I bacterial cytochrome

Alicia N Kreiman, Sarah E Garner, Susan C Carroll, Molly C Sutherland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alicia N KreimanDepartment of Biological Sciences, University of Delaware, Newark, Delaware, USA.
Sarah E GarnerDepartment of Biological Sciences, University of Delaware, Newark, Delaware, USA.
Susan C CarrollDepartment of Biological Sciences, University of Delaware, Newark, Delaware, USA.
Molly C SutherlandDepartment of Biological Sciences, University of Delaware, Newark, Delaware, USA.ORCID 0000-0002-7932-5339

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Shawn W Polson · 2012 to 2026
$67.2M
Chemistry-Biology Interface Predoctoral Training Grant 2024-2029T32GM133395 · NIGMS · UNIVERSITY OF DELAWARE · PI Catherine Leimkuhler Grimes · 2019 to 2026
$3.7M
Heme trafficking in prokaryotic cytochrome c biogenesisR35GM142496 · NIGMS · UNIVERSITY OF DELAWARE · PI SUTHERLAND, MOLLY CUDDY · 2021 to 2025
$2.0M
NIGMS NIH HHS P20 GM103446NIGMS NIH HHS R35 GM142496NIGMS NIH HHS R35GM142496NIGMS NIH HHS T32 GM133395NIGMS NIH HHS T32GM133395University of Delaware Doctoral Fellowship for Excellence
6 · The paper itself

Abstract

Heme is a redox-active cofactor for essential processes across all domains of life. Heme's redox capabilities are responsible for its biological significance but also make it highly cytotoxic, requiring tight intracellular regulation. Thus, the mechanisms of heme trafficking are still not well understood. To address this, the bacterial cytochrome IMPORTANCE: Heme is a biologically important cofactor for proteins involved with essential cellular functions, such as oxygen transport and energy production. Heme can also be toxic to cells and thus requires tight regulation and specific trafficking pathways. As a result, much effort has been devoted to understanding how this important, yet cytotoxic, molecule is transported. While several heme transporters/importers/exporters have been identified, the biochemical mechanisms of transport are not well understood, representing a major knowledge gap. Here, the bacterial cytochrome

Indexed as

Bacterial ProteinsCytochromes cHemeBiological TransportBacterial ProteinsCytochromes cHemecytochrome ccytochrome c biogenesishemeheme traffickingheme transporter

Identifiers

PMID40167305
PMCPMC12077264

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.