Article in The Journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Daniel CastranovaDivision of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-2845-9708
Madeleine I Kenton *Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-9214-6589
Aurora Kraus *Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-1417-5165
Christopher W DellCenter for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, MD, USA.ORCID 0009-0009-2642-5393
Jong S ParkDivision of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7989-4630
Marina Venero GalanternikDivision of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0262-1754
Gilseung ParkSection of Pediatric Hematology-Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.ORCID 0000-0003-3605-8928
Daniel N LumbantobingDivision of Fishes, Department of Vertebrate Zoology, National Museum of Natural History, Smithsonian Institution, Washington, DC, USA.ORCID 0000-0002-1458-1470
Louis DyeMicroscopy and Imaging Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health , Bethesda, MD, USA.ORCID 0009-0003-6957-0095
Miranda MarvelDivision of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-4043-1887
James IbenMolecular Genomics Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health , Bethesda, MD, USA.ORCID 0000-0002-1130-7660
Kiyohito TaimatsuDivision of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0003-0801-2516
Van PhamDivision of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0005-1065-6649
Reegan J WillmsDepartment of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.ORCID 0009-0002-9623-5420
Lucas BlevensSection of Pediatric Hematology-Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.ORCID 0009-0007-1780-4055
Tanner F RobertsonDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0003-4336-3760
Yiran HouDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-6086-6434
Anna HuttenlocherDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-7940-6254
Edan FoleyDepartment of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.ORCID 0000-0001-8666-3267
Lynne R ParentiDivision of Fishes, Department of Vertebrate Zoology, National Museum of Natural History, Smithsonian Institution, Washington, DC, USA.ORCID 0000-0002-3279-7689
J Kimble FrazerSection of Pediatric Hematology-Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.ORCID 0000-0003-2936-2817
Kedar NarayanCenter for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, MD, USA.ORCID 0000-0001-7982-6494
Brant M WeinsteinDivision of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-4136-4962
Funding
WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Regulation of Vascular IntegrityZIAHD008915 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI WEINSTEIN, BRANT · 2011 to 2025
$9.2M
Cell migration and wound repairR35GM118027 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher · 2016 to 2026
$7.5M
Specification&Patterning During Vertebrate OrganogenesisZ01HD001011 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI WEINSTEIN, BRANT M · 1997 to 2008
$1.8M
Mechanisms regulating Meningeal Development and FunctionR00HD098273 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI VENERO GALANTERNIK, MARINA · 2023 to 2025
$742k
Specification And Patterning of the Lymphatic SystemZ01HD008808 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI WEINSTEIN, BRANT · 2007 to 2008
$670k
Mechanical forces regulate leukocyte migration in rapidly deforming tissuesF32GM146398 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERTSON, TANNER FORD · 2022 to 2023
$137k
CIHR MOP77746Hyundai Hope On WheelsIntramural NIH HHS Z01 HD001011Intramural NIH HHS Z01 HD008808Intramural NIH HHS ZIA HD008915National Institute of Child Health and Human Development ZIA-HD008915National Museum of Natural HistoryNCI NIH HHS 75N91019D00024NICHD NIH HHS R00 HD098273NIGMS NIH HHS F32 GM146398NIGMS NIH HHS R35 GM118027NIH HHSOklahoma Center for Adult Stem Cell ResearchUniversity of Oklahoma Health Sciences Center
6 · The paper itself
Abstract
Lymph nodes and other secondary lymphoid organs play critical roles in immune surveillance and immune activation in mammals, but the deep internal locations of these organs make it challenging to image and study them in living animals. Here, we describe a previously uncharacterized external immune organ in the zebrafish ideally suited for studying immune cell dynamics in vivo, the axillary lymphoid organ (ALO). This small, translucent organ has an outer cortex teeming with immune cells, an inner medulla with a mesh-like network of fibroblastic reticular cells along which immune cells migrate, and a network of lymphatic vessels draining to a large adjacent lymph sac. Noninvasive high-resolution imaging of transgenically marked immune cells can be carried out in ALOs of living animals, which are readily accessible to external treatment. This newly discovered tissue provides a superb model for dynamic live imaging of immune cells and their interaction with pathogens and surrounding tissues, including blood and lymphatic vessels.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.