Evidence map›Paper›PMID 40167638›Full record

ArticleActa diabetologica2025

Association between the triglyceride glucose-body roundness index and the incidence of cardiovascular disease among Chinese middle and old-aged adults: a nationwide prospective cohort study.

Wangyang Bai, Hangqi Chen, Huiqin Wan, Xiaofei Ye, Yi Ling, Jinfang Xu, Xiaojing Guo, Jia He

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Article in Acta diabetologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wangyang Bai *School of Medicine, Tongji University, Shanghai, China.ORCID http://orcid.org/0000-0002-6883-4066
Hangqi Chen *School of Medicine, Tongji University, Shanghai, China.
Huiqin Wan *School of Medicine, Tongji University, Shanghai, China.
Xiaofei YeDepartment of Health Statistics, Naval Medical University, Shanghai, China.
Yi LingCollege of Basic Medical Sciences, Naval Medical University, Shanghai, China.
Jinfang XuDepartment of Health Statistics, Naval Medical University, Shanghai, China.
Xiaojing GuoDepartment of Health Statistics, Naval Medical University, Shanghai, China. guoxiaojing1003@163.com.
Jia HeSchool of Medicine, Tongji University, Shanghai, China. hejia63@yeah.net.

Funding

National Nature Science Foundation of China 82073671Scientific research project of Shanghai Municipal Health Commission 202340038Shanghai Emerging Cross Disciplinary Research Project 2022JC011Shanghai Industrial collaborative innovation project 2021-cyxt1-kj10
6 · The paper itself

Abstract

aimPrevious studies have suggested that the triglyceride glucose (TyG) index and body roundness index (BRI) are indicators of insulin resistance (IR) and are associated with the incidence of cardiovascular disease (CVD) among middle and old-aged adults. BRI is considered a more accurate indicator of the proportion of body fat and visceral fat than body mass index (BMI). However, it remains unclear whether the combined use of the TyG index and BRI, specifically the triglyceride glucose-body roundness index (TyG-BRI), is associated with the incidence of CVD among Chinese middle and old-aged adults.

methodsData were obtained from the China Health and Retirement Longitudinal Study (CHARLS). The TyG-BRI index was computed using baseline measurements of triglycerides, fasting blood glucose, waist circumference, and height. Cox proportional hazards regression and restricted cubic spline (RCS) regression analyses were applied to assess the association between the TyG-BRI index and incident CVD (defined as cardiac events or stroke).

resultsA total of 8,113 Chinese adults participated in this study, with a median age of 58 years, including 56.3% males. The fully adjusted Cox regression analysis revealed that individuals in the highest quartile (Q4) of the TyG-BRI index had a 59.1% increased risk of developing incident CVD compared to those in the lowest quartile (HR, 1.591 [95% CI, 1.330-1.902]). The TyG-BRI index showed a significant linear association with CVD incidence (P for nonlinearity = 0.447, P < 0.001). This association persisted after conducting subgroup and sensitivity analyses.

conclusionsThis study introduced a novel TyG-BRI index, which integrated IR and body roundness as a comprehensive indicator, demonstrating its strong and independent association with increased CVD risk in a Chinese nationwide cohort. Our findings provide new insights into the interaction between metabolic dysfunction and cardiovascular risk, suggesting that the TyG-BRI index could serve as a practical tool for targeted preventive interventions.

Indexed as

Blood GlucoseCardiovascular DiseasesTriglyceridesAgedBody Mass IndexChinaEast Asian PeopleFemaleHumansIncidenceInsulin ResistanceLongitudinal StudiesMaleMiddle AgedProspective StudiesRisk FactorsBlood GlucoseTriglyceridesCardiovascular diseaseCHARLSTriglyceride glucose-body roundness index

Identifiers

PMID40167638

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.