Evidence map›Paper›PMID 40167803›Full record

Trial reportArchives of dermatological research2025

Fractional CO2 laser with topical insulin versus PRP for atrophic acne scars: a randomized split-face study.

Mahmoud A Rageh, Emad M Elrewiny, Ahmed S Kadah, Hazem B Zakaria, Mohamed Abdelshakour, Sara M Mohy, Waleed Ahmed Mahmoud, Ahmed A Suliman, Ahmed Abdelkader Mohamed

Abstract readRandomized Controlled TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mahmoud A RagehDepartment of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. dr.mahmoudrageh@azhar.edu.eg.ORCID http://orcid.org/0000-0001-6212-9748
Emad M ElrewinyDepartment of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ahmed S KadahDepartment of Dermatology, Faculty of Medicine for Girls, Al-Azhar University, New Damietta, Egypt.ORCID http://orcid.org/0000-0001-9744-9506
Hazem B ZakariaDepartment of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mohamed AbdelshakourDepartment of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Sara M MohyDepartment of Dermatology, Faculty of Medicine, Misr University for Science and Technology (MUST), Giza, Egypt.ORCID http://orcid.org/0009-0008-6879-3728
Waleed Ahmed MahmoudDepartment of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ahmed A SulimanDepartment of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ahmed Abdelkader MohamedDepartment of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrophic acne scarring is a prevalent problem that has been treated with a variety of procedures, each with various degrees of success. For better results, combined regimens of treatment are recommended. Our aim was to compare the efficacy of topical insulin against topical platelet-rich plasma (PRP) as an adjunct treatment to fractional CO2 laser for atrophic acne scars. The study comprised 30 patients with atrophic acne scars. All patients underwent four sessions of fractional CO2 laser on both sides of the face at one-month intervals, followed by topical PRP treatment on one side of the face and topical insulin on the other. Two non-treating dermatologists used the Acne Scar Assessment Scale (ASAS) to assess the outcome. At their last follow-up appointment, patients were asked to assess their improvement on each side of the face in a percentage from 0 to 100%. Prior to treatment, there was no difference in the ASAS scores between the two sides of the face. One month after the last treatment session, ASAS scores improved significantly on both sides of the face. No significant difference (p = 0.794) between both sides were detected. Both techniques helped to improve atrophic acne scars and may have a synergistic outcome regarding efficacy and safety.

Indexed as

Acne VulgarisCicatrixInsulinLasers, GasPlatelet-Rich PlasmaAdministration, TopicalAdolescentAdultAtrophyCombined Modality TherapyFaceFemaleHumansMaleTreatment OutcomeYoung AdultInsulinAcneAcne scarsFractional laserInsulinPlatelet-rich plasma

Identifiers

PMID40167803

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.