ArticleMethods in molecular biology (Clifton, N.J.)2025
A Comprehensive Workflow for Cerebrospinal Fluid Proteomics in the Study of Brain Tumors.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The cerebrospinal fluid (CSF) plays a critical role in maintaining homeostasis within the central nervous system (CNS). Detecting protein alterations in CSF associated with brain tumors offers a unique opportunity to enhance diagnosis, prognosis, recurrence monitoring, and treatment response. As an extracellular component of the CNS, it serves as a valuable reservoir of biomarkers that reflect changes associated with brain tumors-biomarkers that are often difficult to detect in the systemic circulation due to the blood-brain barrier. Advances in liquid biopsy techniques for CSF, coupled with high-throughput technologies, have the potential to significantly benefit patients. Here, we provide a comprehensive overview of methodologies for studying the CSF proteome to identify brain tumor-associated alterations.
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