ArticlePloS one2025
Red blood cell distribution width to albumin ratio as a novel predictor for mortality in chronic obstructive pulmonary disease patients: Results from the cohort study of NHANES, 1999-2018.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Aortic Elastic Properties and Albumin-Based Inflammatory Indices in Dyspneic Third-Trimester Pregnant Women: A Prospective Observational Study.Biomedicines · 2026Article
- Association between red blood cell distribution width-to-albumin ratio and risk of low lean mass: A cross-sectional study of NHANES 1999-2018.Science progressArticle
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Authors and funding
3 authors.
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Abstract
objectivesTo investigate the association of red blood cell distribution width (RDW) to albumin ratio (RAR) with mortality in chronic obstructive pulmonary disease (COPD) patients.
methodsWe selected 1,652 patients with COPD from the National Health and Nutrition Examination Survey (NHANES) 1999-2018, who were categorized into four groups according to the RAR quartiles. Kaplan-Meier curves, restricted cubic splines and the Cox proportional hazard model were used to evaluate the associations between RAR and all-cause mortality and chronic lower respiratory disease (CLRD) mortality in the COPD patients. Subgroup analyses were performed to check the interaction of the different characteristics.
resultsThere were 640 deaths during follow-up, of which, 145 were from CLRD. Kaplan-Meier curves indicated COPD patients with higher RAR had significantly increased all-cause mortality and CLRD mortality. Multivariate Cox regression analyses showed HR of Q4 RAR was 2.88 (95% CI 2.18 - 3.81, p < 0.0001) for all cause-mortality and 3.39 (95% CI 1.76 - 6.53, p < 0.001) for CLRD mortality, compared with Q1 RAR. Restricted cubic splines analysis indicated a dose-response between RAR and risk of all-cause and CLRD mortality (p for non-linearity < 0.001).
conclusionRAR had an independent association with all-cause mortality, especially CLRD mortality, in COPD patients. RAR has potential as a novel and promising predictor to identify COPD individuals with high mortality risk.
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