Observational studyNeurology2025
Brain Network Functional Connectivity in Children With a Concussion.
Observational study in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- ComBat Harmonization With and Without Empirical Bayes Estimation for Resting-State Functional Connectivity in Pediatric Mild Traumatic Brain Injury: a CARE4Kids Study.Research square · 2026Article
- Sexual Dimorphisms in Neurodevelopment May Affect TBI Recovery in Pediatric Patients.Biomedicines · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesPediatric concussion can disrupt functional brain network connectivity, but prospective longitudinal research is needed to clarify recovery and identify moderators of change. This study investigated network functional connectivity (FC) up to 6 months after pediatric concussion.
methodsThis prospective longitudinal concurrent cohort observational study consecutively recruited children (aged 8 to 17 years) at 5 Canadian pediatric hospital emergency departments within 48 hours of sustaining a concussion or mild orthopaedic injury (OI). Children completed 3T MRI scanning postacutely (2 to 33 days) and at either 3 or 6 months after injury (randomly assigned at the postacute visit). Reliable change between retrospective preinjury (based on parent report) and 1-month postinjury symptom ratings based on parent and child report was used to classify concussion with or without persisting symptoms. Within-network and between-network FC was computed for 8 brain networks from resting-state fMRI scans and analyzed using linear mixed-effects models, with multiple comparison correction.
resultsGroups (385 with concussion/198 with OI; 59% male; 69% White; age 12.42 ± 2.29 years) did not differ in within-network FC. Relative to OI, connectivity between the visual and ventral attention networks was lower after concussion, DISCUSSION: Time after injury, age at injury, biological sex, and persistent symptom status are important moderators of FC after pediatric concussion for children seen in emergency department settings. Postacute FC may not enhance clinical diagnosis. Although within-network connectivity is preserved, between-network connectivity differences emerge after most children clinically recover and persist up to 6 months after pediatric concussion, providing a potential objective biomarker for lasting changes in brain function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.