Evidence map›Paper›PMID 40169519›Full record

ArticleHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2025

Sex Differences in Ambulatory Central Blood Pressure and Arterial Stiffness in Hemodialysis Patients.

Artemios G Karagiannidis, Marieta P Theodorakopoulou, Fotini Iatridi, Antonios Karpetas, Areti Georgiou, Sofia Manti, Panagiota Anyfanti, Eleni Gavriilaki, George Giannakoulas, Pantelis Sarafidis

Abstract readComparative Study
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In one paragraph

Article in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Artemios G KaragiannidisFirst Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID http://orcid.org/0000-0002-7054-1422
Marieta P TheodorakopoulouFirst Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. marietatheod@gmail.com.ORCID http://orcid.org/0000-0001-6216-9635
Fotini IatridiFirst Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Antonios KarpetasTherapeutiki Hemodialysis Unit, Thessaloniki, Greece.
Areti GeorgiouFirst Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Sofia MantiFirst Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Panagiota AnyfantiThird Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Eleni GavriilakiSecond Propaedeutic Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
George GiannakoulasFirst Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Pantelis SarafidisFirst Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSex differences have a significant role on epidemiology of cardiovascular complications in chronic kidney disease. Among hemodialysis patients, central blood pressure (BP) levels and increased arterial stiffness parameters are independent predictors of cardiovascular and all-cause- mortality.

aimTo examine the potential differences in ambulatory central BP and arterial stiffness parameters between male and female hemodialysis patients.

methodsA total of 129 male and 91 female hemodialysis patients were included in this analysis. All participants underwent 48-h ambulatory BP monitoring with Mobil-O-Graph-NG; indices of central hemodynamics (SBP, DBP and pulse pressure), wave reflection (augmentation pressure (AP) and augmentation index (AIx)) and pulse wave velocity (PWV) were estimated.

resultsAge, dialysis vintage and history of major comorbidities did not differ between men and women. Male patients had higher 48-h cSBP (124.7±15.7 vs. 119.8±16.7 mmHg, p=0.027) and 48-h DBP (83.7±12.2 vs. 77.5±11.9 mmHg, p<0.001) compared to female patients; relevant differences were also evident during the 44-h (excluding hemodialysis), 1st 24-h and 2nd 24-h periods and the corresponding daytime and nighttime periods of the recording. Central pulse pressure did not differ between groups. Regarding wave reflection parameters, AP, AIx, and AIx(75) were significantly lower in males versus females during the 48-h (AIx, 25.6±8.2 vs. 32.3±8.6 mmHg, p<0.001), 44-h, 1st and 2nd 24-h and also during respective daytime and nighttime periods. The two groups displayed similar PWV during all studied intervals (48-h PWV, 9.6±1.9 vs 9.7±2.1 m/s, p=0.612).

conclusionsMale hemodialysis patients present with higher levels of ambulatory central BP but significantly lower levels of AP, AIx and AIx(75) than females. PWV does not differ between sexes.

Indexed as

Blood PressureBlood Pressure Monitoring, AmbulatoryHealth Status DisparitiesRenal DialysisRenal Insufficiency, ChronicVascular StiffnessAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedPredictive Value of TestsPulse Wave AnalysisRisk AssessmentArterial stiffnessAugmentation indexCentral blood pressureHemodialysisPulse wave velocitySex differences

Identifiers

PMID40169519

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.