Evidence map›Paper›PMID 40169574›Full record

ArticleNature communications2025

Exercise-induced anti-obesity effects in male mice generated by a FOXO1-KLF10 reinforcing loop promoting adipose lipolysis.

Jie-Ying Zhu, Min Chen, Wang-Jing Mu, Hong-Yang Luo, Yang Li, Shan Li, Lin-Jing Yan, Ruo-Ying Li, Meng-Ting Yin, Xin Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jie-Ying ZhuSchool of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, China.ORCID http://orcid.org/0009-0008-5943-2920
Min ChenSchool of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, China.ORCID http://orcid.org/0009-0000-8956-0028
Wang-Jing MuSchool of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, China.ORCID http://orcid.org/0000-0002-7131-0394
Hong-Yang LuoSchool of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, China.ORCID http://orcid.org/0000-0001-8657-255X
Yang LiSchool of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, China.ORCID http://orcid.org/0009-0008-7965-3317
Shan LiSchool of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, China.ORCID http://orcid.org/0009-0009-9481-7022
Lin-Jing YanSchool of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, China.ORCID http://orcid.org/0009-0004-1661-7221
Ruo-Ying LiSchool of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, China.ORCID http://orcid.org/0009-0000-9204-6353
Meng-Ting YinSchool of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, China.ORCID http://orcid.org/0009-0005-6491-4893
Xin LiSchool of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, China.ORCID http://orcid.org/0009-0005-5800-5829
Hu-Min ChenSchool of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, China.ORCID http://orcid.org/0009-0004-8825-0027
Liang GuoSchool of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, China. guoliang@sus.edu.cn.ORCID http://orcid.org/0000-0001-7353-8336

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32070751
6 · The paper itself

Abstract

Exercise combats obesity and metabolic disorders, but the underlying mechanism is incompletely understood. KLF10, a transcription factor involved in various biological processes, has an undefined role in adipose tissue and obesity. Here, we show that exercise facilitates adipocyte-derived KLF10 expression via SIRT1/FOXO1 pathway. Adipocyte-specific knockout of KLF10 blunts exercise-promoted white adipose browning, energy expenditure, fat loss, glucose tolerance in diet-induced obese male mice. Conversely, adipocyte-specific transgenic expression of KLF10 in male mice enhanced the above metabolic profits induced by exercise. Mechanistically, KLF10 interacts with FOXO1 and facilitates the recruitment of KDM4A to form a ternary complex on the promoter regions of Pnpla2 and Lipe genes to promote these key lipolytic genes expression by demethylating H3K9me3 on their promoters, which facilitates lipolysis to defend against obesity in male mice. As a downstream effector responding to exercise, adipose KLF10 could act as a potential target in the fight against obesity.

Indexed as

Adipose TissueEarly Growth Response Transcription FactorsForkhead Box Protein O1Kruppel-Like Transcription FactorsLipolysisObesityPhysical Conditioning, AnimalAcyltransferasesAdipocytesAdipose Tissue, WhiteAnimalsDiet, High-FatEnergy MetabolismJumonji Domain-Containing Histone DemethylasesLipaseMaleAcyltransferasesEarly Growth Response Transcription FactorsForkhead Box Protein O1Foxo1 protein, mouseJumonji Domain-Containing Histone DemethylasesKLF10 protein, mouseKruppel-Like Transcription FactorsLipaseMembrane ProteinsPNPLA2 protein, mouseSirt1 protein, mouseSirtuin 1

Identifiers

PMID40169574
PMCPMC11961606

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.