Causal association between dietary factors and telomere length revealed by mendelian randomization.

Xinghai Yue, Hongfei Liu, Wenzhao Guo, Yuhang Gao, Shaoshun Shi

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Xinghai Yue *Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.

Hongfei Liu *Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.

Wenzhao GuoLiaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.

Yuhang GaoLiaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.

Shaoshun ShiLiaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China. 18940039908@163.com.

Funding

XingLiaoYingCai Program YXMJ-QNMZY-13

6 · The paper itself

Abstract

Observational studies have reported associations between dietary factors and telomere length. However, the inherent limitations of observational study designs render them susceptible to confounding and reverse causation biases. Therefore, this study aims to explore the association between dietary factors and telomere length using Mendelian Randomization (MR) to minimize the influence of confounding factors and reverse causality. The IEU Open GWAS project was the source of exposure and outcome datasets. The exposure datasets included 20 dietary factors. We conducted MR analyses to explore the relationship between dietary factors and telomere length. We used MRPRESSO and Radial-MR test to identify any level of multi-effect outliers. Heterogeneity and pleiotropic analysis were performed to ensure the accuracy of the results. The stability of the effect of significant results is assessed using multivariable Mendelian randomization (MVMR) and MR-lap. Two-sample MR analysis revealed a statistically significant association between dried fruit intake and telomere length (β = 0.223, 95% CI 0.091 to 0.356, P

Indexed as

DietMendelian Randomization AnalysisTelomereTelomere HomeostasisCausalityFruitGenome-Wide Association StudyHumansPolymorphism, Single NucleotideAgingDietary factorsDried fruit intakeMendelian randomizationTelomere length

Identifiers

PMID40169648

DOI10.1038/s41598-025-87693-2

PMCPMC11961733

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.