Evidence map›Paper›PMID 40169971›Full record

SynthesisBMC cancer2025

Role of Cancer Associated Fibroblast (CAF) derived miRNAs on head and neck malignancies microenvironment: a systematic review.

Parsa Golestannejad, Mohamadparsa Monkaresi, Farahnaz Zhian Zargaran, Mohammad Khosravani, Pouya Asgari, Hesam Mobaraki, Mansour Gorjizad, Saina Hasany, Aliakbar Senobari Ghezeljehmeidan, Sara Hemmati and 3 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
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  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Parsa Golestannejad *Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Mohamadparsa Monkaresi *Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Farahnaz Zhian Zargaran *Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran.
Mohammad KhosravaniDepartment of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Pouya AsgariAhvaz Jondishapur University of Medical Sciences, Ahvaz, Iran.
Hesam MobarakiFaculty of Medicine, İStanbul Yeniyuzyil University, Istanbul, Turkey.
Mansour GorjizadSchool of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Saina HasanyIslamic Azad University Tehran Medical Sciences, Tehran, Iran.
Aliakbar Senobari GhezeljehmeidanYıldırım Beyazıt University, Ankara, Turkey.
Sara HemmatiGulian University of Medical Sciences, Rasht, Iran.
Samaneh ZandShahid Beheshti University of Medical Science, Tehran, Iran.
Parsa GhasemiSchool of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Mahsa Asadi AnarStudent Research Committee, Shahid Beheshti University of Medical Sciences, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, 19839-63113, Iran. Mahsa.boz@gmail.com.ORCID http://orcid.org/0000-0002-5772-2472

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimMicroRNAs (miRNAs) play a key role in regulating gene expression within the tumor microenvironment, influencing cancer progression and therapy response. Cancer-associated fibroblasts (CAFs) contribute to tumor development by secreting exosomal miRNAs that promote proliferation, invasion, and resistance. This systematic review evaluates the impact of CAF-derived miRNAs on head and neck malignancies.

methodsA systematic search was conducted in PubMed, Scopus, WOS, and Google Scholar following PRISMA guidelines. Studies focusing on CAF-derived miRNAs in head and neck cancers were included. Data extraction covered study characteristics, miRNA profiling methods, functional roles, and clinical significance. The Scirap tool was used for quality assessment.

resultsAmong 921 identified articles, 21 met the inclusion criteria. Findings indicate that miR-21-5p, miR-106-5p, and miR-196a drive tumor progression in oral squamous cell carcinoma (OSCC), while miR-124 and miR-34a-5p act as suppressors. In esophageal squamous cell carcinoma (ESCC), miR-21 and miR-27a/b contribute to chemotherapy resistance, whereas miR-100-5p inhibits lymphangiogenesis. In head and neck squamous cell carcinoma (HNSCC), miR-196a and miR-196b may serve as diagnostic biomarkers. Exosomal miR-106a-5p promotes nasopharyngeal carcinoma (NPC) metastasis, and miR-7 and miR-196a contribute to therapy resistance in head and neck cancer (HNC).

conclusionCAF-derived miRNAs significantly influence tumor progression, metastasis, and therapy resistance. These findings highlight their potential as biomarkers and therapeutic targets, warranting further clinical research for personalized treatment strategies.

Indexed as

Cancer-Associated FibroblastsHead and Neck NeoplasmsMicroRNAsTumor MicroenvironmentBiomarkers, TumorDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHumansSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorMicroRNAsCAFCancer-associated fibroblastHead and neck malignancyMiRNATumor microenvironment

Identifiers

PMID40169971
PMCPMC11960023

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.