ArticleBrain and behavior2025
The Vestibulo-Ocular Reflex is Associated With Visuospatial Dysfunction in Patients With Parkinson's Disease.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of vestibulo-ocular reflex dysfunction in people with neurological disorders: a systematic review and meta-analysis.Journal of neurology · 2026Pooled it
- The Vestibulo-Ocular Reflex is Associated With Visuospatial Dysfunction in Patients With Parkinson's Disease.Brain and behavior · 2025Article
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11 authors.
Funding
Abstract
backgroundVisuospatial impairment is one of the most frequent cognitive deficits in patients with Parkinson's disease (PD). It remains unknown whether the vestibulo-ocular reflex (VOR) function affects visuospatial perception and memory in patients with PD.
objectiveTo delineate the relationship between VOR and visuospatial function in patients with PD.
methodsWe prospectively evaluated video head-impulse tests in 151 patients with PD (mean age
resultsRCFT-copying and RCFT-delayed recall were impaired in 11 (11/151, 7%) and 15 (15/151, 10%) patients, respectively. The VOR gain was normal in 55 patients with PD (55/151, 36%). However, 69 patients overestimated VOR gain for at least one canal, and 34 patients showed a decreased gain for at least one canal (seven patients showed an overestimated gain for some canals and decreased gain for other canals). Multivariable logistic regression analysis showed that abnormal RCFT-copying was negatively associated with the VOR gain for the horizontal canal (odds ratio [OR]: 0.001, 95% confidence interval [CI]: 0.001-0.08, p = 0.007). In contrast, abnormal RCFT-delayed recall was negatively associated with Mini-Mental State Examination scores (0.70, 0.52-0.93, p = 0.013), positively with age (1.11, 1.00-1.22, p = 0.041), male sex (12.82, 1.17-142.86, p = 0.036), years of schooling (1.41, 1.09-1.82, p = 0.009), but not with the VOR gain for any canal.
conclusionsThe VOR function may be associated with deficits in visuospatial perception and learning in patients with PD. This implicates the development of more targeted therapeutic interventions and offers insights into the broader implications of PD on sensory-motor integration and cognitive function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.