Evidence map›Paper›PMID 40171539›Full record

ArticleFrontiers in cardiovascular medicine2025

Cardiac preservation using

William D Carlson, Dattatreyamurty Bosukonda, Peter C Keck, Philippe Bey, Shannon N Tessier, Frederic R Carlson

Abstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

William D CarlsonDivision of Cardiology, Mass General Hospital/Harvard, Boston, MA, United States.
Dattatreyamurty BosukondaDivision of Cardiology, Mass General Hospital/Harvard, Boston, MA, United States.
Peter C KeckTherapeutics by Design, Weston, MA, United States.
Philippe BeyTherapeutics by Design, Weston, MA, United States.
Shannon N TessierCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, and Shriners Children's Hospital, Boston, MA, United States.
Frederic R CarlsonTherapeutics by Design, Weston, MA, United States.

Funding

High subzero heart preservation: from zebrafish to mammalsR01HL157803 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Shannon Noella Tessier · 2021 to 2026
$2.8M
Cryopreservation of zebrafish larvae and embryos for biomedical researchR24OD034189 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI Shannon Noella Tessier · 2023 to 2026
$2.6M
A quantitative viability metric for liver transplantation using Resonance Raman SpectroscopyR01DK134590 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Shannon Noella Tessier · 2023 to 2026
$1.9M
NHLBI NIH HHS R01 HL157803NIDDK NIH HHS R01 DK134590NIH HHS R24 OD034189
6 · The paper itself

Abstract

As heart transplantation continues to be the gold standard therapy for end-stage heart failure, the imbalance between the supply of hearts, and the demand for them, continues to get worse. In the US alone, with less than 4,000 hearts suitable for transplant and over 100,000 potential recipients, this therapy is only available to a very few. The use of hearts Donated after Circulatory Death (DCD) and Donation after Brain Death (DBD) using

Indexed as

BMPBone morphogenetic proteinEx-vivo heart machine perfusionmimeticsNMPTGFTHR-123THR-184

Identifiers

PMID40171539
PMCPMC11960666

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.