Evidence map›Paper›PMID 40171669›Full record

ArticleStroke2025

Small Extracellular Vesicles From Hypoxia-Neuron Maintain Blood-Brain Barrier Integrity.

Wei Chen, Yousheng Wu, Ying Liang, Xuanlin Su, Man Ke, Die Deng, Jiankun Zang, Jielin Zhu, Hongcheng Mai, Anding Xu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wei Chen *Department of Neurology and Stroke Center (W.C., Y.W., Y.L., X.S., M.K., D.D., J. Zang, A.X., D.L.), The First Affiliated Hospital of Jinan University, Guangzhou, China.
Yousheng Wu *Department of Neurology and Stroke Center (W.C., Y.W., Y.L., X.S., M.K., D.D., J. Zang, A.X., D.L.), The First Affiliated Hospital of Jinan University, Guangzhou, China.
Ying Liang *Department of Neurology and Stroke Center (W.C., Y.W., Y.L., X.S., M.K., D.D., J. Zang, A.X., D.L.), The First Affiliated Hospital of Jinan University, Guangzhou, China.ORCID 0009-0001-4639-0804
Xuanlin Su *Department of Neurology and Stroke Center (W.C., Y.W., Y.L., X.S., M.K., D.D., J. Zang, A.X., D.L.), The First Affiliated Hospital of Jinan University, Guangzhou, China.ORCID 0000-0003-3602-295X
Man KeDepartment of Neurology and Stroke Center (W.C., Y.W., Y.L., X.S., M.K., D.D., J. Zang, A.X., D.L.), The First Affiliated Hospital of Jinan University, Guangzhou, China.
Die DengDepartment of Neurology and Stroke Center (W.C., Y.W., Y.L., X.S., M.K., D.D., J. Zang, A.X., D.L.), The First Affiliated Hospital of Jinan University, Guangzhou, China.
Jiankun ZangDepartment of Neurology and Stroke Center (W.C., Y.W., Y.L., X.S., M.K., D.D., J. Zang, A.X., D.L.), The First Affiliated Hospital of Jinan University, Guangzhou, China.
Jielin ZhuDepartment of Neurology, The Affiliated Shunde Hospital of Jinan University, Foshan, China (J. Zhu).
Hongcheng MaiDepartment of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China (H.M.).
Anding XuDepartment of Neurology and Stroke Center (W.C., Y.W., Y.L., X.S., M.K., D.D., J. Zang, A.X., D.L.), The First Affiliated Hospital of Jinan University, Guangzhou, China.ORCID 0000-0003-3154-0985
Dan LuDepartment of Neurology and Stroke Center (W.C., Y.W., Y.L., X.S., M.K., D.D., J. Zang, A.X., D.L.), The First Affiliated Hospital of Jinan University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute ischemic stroke disrupts communication between neurons and blood vessels in penumbral areas. How neurons and blood vessels cooperate to achieve blood-brain barrier repair remains unclear. Here, we reveal crosstalk between ischemic penumbral neurons and endothelial cells (ECs) mediated by circular RNA originating from oxoglutarate dehydrogenase (CircOGDH).

methodsWe analyzed clinical data from patients with acute ischemic stroke to explore the relationship between CircOGDH levels and hemorrhagic transformation events. In addition, a middle cerebral artery occlusion and reperfusion mouse model with neuronal CircOGDH suppression was used to assess endothelial permeability. ECs with increased CircOGDH expression were analyzed for changes in COL4A4 (collagen type IV alpha 4) levels, and in vitro coculture experiments were conducted to examine small extracellular vesicle-mediated CircOGDH transfer between neurons and ECs.

resultsClinical data indicated that reduced CircOGDH levels were correlated with increased hemorrhagic transformation in patients with acute ischemic stroke. In the middle cerebral artery occlusion and reperfusion model, neuronal CircOGDH suppression impaired the restoration of endothelial permeability. ECs with increased CircOGDH expression exhibited higher COL4A4 levels, which helped maintain vascular stability. In vitro, hypoxic neurons transferred CircOGDH to ECs via small extracellular vesicles, leading to elevated COL4A4 expression and enhanced endothelial integrity.

conclusionsOur findings highlight the significance of CircOGDH in neuron-EC crosstalk via small extracellular vesicles in the ischemic penumbra, emphasizing the need for balanced intervention strategies in acute ischemic stroke management.

Indexed as

Blood-Brain BarrierExtracellular VesiclesIschemic StrokeNeuronsAnimalsCollagen Type IVEndothelial CellsFemaleHumansInfarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLMiddle AgedRNA, CircularCollagen Type IVRNA, Circularblood-brain barriercircular RNAendothelial cellsischemic strokeneurovascular coupling

Identifiers

PMID40171669
PMCPMC12101896

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.