Trial reportJournal of cachexia, sarcopenia and muscle2025
Long-Term Effects of High-Intensity Aerobic Training on Metabolic Syndrome: An 8-Year Follow-Up Randomized Clinical Trial.
Trial report in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Pooled it
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- Exploring the Impact of Initiating Endocrine Therapy on Metabolic Health in Early Breast Cancer: Protocol for the Prospective Follow-Up EMETA-Study.JMIR research protocols · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundMetabolic syndrome (MetS) is a set of five cardiometabolic risk factors that typically worsen with age. One exercise-training programme is effective at improving those factors in middle-aged individuals with MetS. To our knowledge, exercise-training efficacy as MetS individuals age has not been explored. This study determined the effectiveness of a periodized exercise training programme for individuals with MetS after a follow-up period of 8 years.
methodsForty-seven individuals with MetS were block-randomized into an EXERCISE (n = 22, 52 ± 8 years old, 23% women) or a CONTROL group (n = 25, 53 ± 8 years old, 32% women). Both groups received standard health care, including medical counselling and lifestyle advice at least every 6 months, while participants in EXERCISE also underwent a supervised exercise programme. The intervention lasted 8 years and consisted of 4 months per year (November to March) of high-intensity interval training thrice weekly. At baseline, and after 4 and 8 years of treatment, we assessed body composition, MetS components (i.e., MetS Z score), medication use, cardiorespiratory fitness (CRF; assessed by VO
resultsParadoxically, MetS Z score and body weight were reduced after 8 years (subjects aged from 52 to 60 years old) in both groups (time effect p < 0.001 and p = 0.008; time × group interaction p = 0.253 and p = 0.130). However, in those 8 years, the medicine use score increased threefold in CONTROL (137% increase; from 1.7 to 3.9; p < 0.001) while it did not change in EXERCISE (33%; from 2.0 to 2.7; p = 0.066). In 8 years, CRF and W
conclusionsOur data suggest that annual exercise training has similar clinical efficacy to triple oral medication for the management of MetS in individuals aged 50 to 60 years. The health of individuals with cardiometabolic disorders can be maintained as they age by increasing medication or by participating in an annual intensive exercise programme.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.